Departament de Química Analítica, Universitat de Barcelona, Martí i Franquès, 1-11, E-08028 Barcelona, Spain.
Anal Chim Acta. 2012 Oct 9;746:47-52. doi: 10.1016/j.aca.2012.08.005. Epub 2012 Aug 14.
A recently developed methodology, which combines voltammetry, ITC, ESI-MS and several chemometric tools, has been applied for the first time to the study of As(III) complexes. The ligands considered, DMSA and DMPS, are commonly used to treat heavy metal poisoning. The study yields a reliable and consistent picture of the binding of As(III) by the chelating therapy agents DMSA and DMPS providing an unambiguous description of the stoichiometries of the complexes (ML(2), with the occasional appearance of ML in the case of DMSA), both ligands have stability constants of the same order, with a logβ(2) of 9.2 and 9.8, respectively. These values confirm the potential efficiency of both ligands in the treatment of As(III) poisoning.
一种新开发的方法，结合伏安法、ITC、ESI-MS 和几种化学计量学工具，首次应用于研究 As(III)配合物。所考虑的配体 DMSA 和 DMPS 通常用于治疗重金属中毒。该研究提供了关于螯合治疗剂 DMSA 和 DMPS 与 As(III)结合的可靠且一致的图像，明确描述了配合物的化学计量比（ML(2)，在 DMSA 的情况下偶尔会出现 ML），两种配体的稳定性常数处于同一数量级，分别为 logβ(2)为 9.2 和 9.8。这些值证实了两种配体在治疗 As(III)中毒方面的潜在效率。
