Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China.
Gene. 2012 Dec 1;510(2):185-8. doi: 10.1016/j.gene.2012.09.003. Epub 2012 Sep 10.
A number of studies reported on associations of single nucleotide polymorphisms (SNPs) present in chromosome 9p21 with early-onset coronary artery disease (CAD). The present study was then undertaken to perform a meta-analysis of all the results published to date.
All studies of the 9p21 association with early-onset CAD that were published between 2007 and 2012 were retrieved from the PubMed database. RevMan 5.0 software was used to perform meta-analysis of the data that fulfilled the criteria for our meta-analysis. The effect size of four SNPs in the 9p21 region on early-onset CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI).
A total of 7123 subjects from 7 case-control studies were genotyped. Meta-analysis demonstrated disease association for rs2383207 (OR=0.79, 95% CI 0.71-0.88, P<0.0001), rs2383206 (OR=1.17, 95% CI 1.10-1.25, P<0.00001), rs10757278 (OR=1.28, 95% CI 1.15-1.42, P<0.00001), and rs10757274 (OR=1.17, 95% CI 1.08-1.33, P=0.02).
Genetic variation in the chromosome 9p21 region may contribute to the etiology of early-onset CAD although their effect size is rather small.
多项研究报道了位于 9 号染色体 21 上的单核苷酸多态性（SNP）与早发冠心病（CAD）的关联。本研究旨在对迄今为止发表的所有结果进行荟萃分析。
从 PubMed 数据库中检索了 2007 年至 2012 年间发表的关于 9p21 与早发 CAD 关联的所有研究。使用 RevMan 5.0 软件对符合我们荟萃分析标准的数据进行荟萃分析。基于比值比（OR）计算，评估 9p21 区域的四个 SNP 对早发 CAD 风险的影响大小，计算 95%置信区间（CI）。
共有 7123 名来自 7 项病例对照研究的个体进行了基因分型。荟萃分析显示 rs2383207（OR=0.79，95%CI 0.71-0.88，P<0.0001）、rs2383206（OR=1.17，95%CI 1.10-1.25，P<0.00001）、rs10757278（OR=1.28，95%CI 1.15-1.42，P<0.00001）和 rs10757274（OR=1.17，95%CI 1.08-1.33，P=0.02）与疾病相关。
尽管染色体 9p21 区域的遗传变异对早发 CAD 的病因学有一定贡献，但它们的效应大小相当小。
