Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK.
Prog Biophys Mol Biol. 2013 Apr;111(2-3):129-36. doi: 10.1016/j.pbiomolbio.2012.08.015. Epub 2012 Sep 10.
Systems biology is centrally engaged with computational modelling across multiple scales and at many levels of abstraction. Formal modelling, precise and formalised abstraction relationships, and computation also lie at the heart of computer science--and over the past decade a growing number of computer scientists have been bringing their discipline's core intellectual and computational tools to bear on biology in fascinating new ways. This paper explores some of the apparent points of contact between the two fields, in the context of a multi-disciplinary discussion on conceptual foundations of systems biology.
系统生物学主要涉及跨多个尺度和多个抽象层次的计算建模。形式建模、精确和形式化的抽象关系以及计算也是计算机科学的核心——在过去的十年中，越来越多的计算机科学家以令人着迷的新方式将他们学科的核心知识和计算工具应用于生物学。本文在关于系统生物学概念基础的多学科讨论背景下，探讨了这两个领域之间的一些明显的联系点。
