人源性肉瘤中 p53 的再激活策略。
Strategies for p53 reactivation in human sarcoma.
机构信息
Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.
出版信息
Cancer Cell. 2012 Sep 11;22(3):283-5. doi: 10.1016/j.ccr.2012.08.020.
PMID:22975370
Abstract
Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.
摘要
癌症治疗领域的新兴策略将基因组突变和蛋白质组景观联系起来，从而可以对靶标选择进行智能推理。在本期《癌细胞》杂志中，Piccinin 及其同事利用这种方法证明了间质蛋白 Twist1 抑制 p53，为人类肉瘤中 p53 的重新激活提供了一个新的靶标。
Zotero 插件