Department of Cardiac Surgery, Heartcenter Dresden, University Hospital, Dresden, Germany.
Clin Hemorheol Microcirc. 2012;52(2-4):217-27. doi: 10.3233/CH-2012-1599.
Heart failure patients are clinically characterized by extreme cardiomegaly, breathlessness, fluid retention and an early onset of fatigue. Studies have shown generalized restricted blood flow in those patients. Furthermore animal experiments proved an impaired blood flow and a diminished oxygen supply of the skeletal muscle in animals with chronic heart failure. Patients with chronic heart failure are limited to the extent of their ability to regulate their arterial pressure, especially in physical activity. It is however unclear in what way restriction of blood flow in the main arteries correlates with those in capillaries and to what extent. In this study it was examined the depth of capillary circulatory restriction as well as the disregulation of oxygen partial pressure in skeletal muscle in rest and stress conditions, in patients with terminal heart failure.
心力衰竭患者的临床特征是心脏极度肿大、呼吸困难、体液潴留和疲劳早发。研究表明，这些患者的全身血流受限。此外，动物实验证明，患有慢性心力衰竭的动物的骨骼肌血流减少，氧气供应减少。慢性心力衰竭患者的动脉血压调节能力受到限制，尤其是在体力活动时。然而，目前尚不清楚主要动脉血流受限与毛细血管血流受限的程度以及毛细血管血流受限的程度。在这项研究中，研究了终末期心力衰竭患者在休息和应激状态下骨骼肌毛细血管循环受限的深度以及氧分压失调的情况。
