Drexler H, Coats A J
Medizinische Klinik III, University of Freiburg, Germany.
Annu Rev Med. 1996;47:241-56. doi: 10.1146/annurev.med.47.1.241.
Fatigue is a prominent symptom in patients with chronic heart failure, limiting physical activity and impairing quality of life. Although the underlying mechanisms are not clearly identified, alterations associated with peripheral adaptation in heart failure appear to play an important role, including a variably impaired peripheral perfusion during exercise, reduced oxidative capacity of skeletal muscle, impaired muscle strength, and possibly reflex mechanisms associated with alterations in the metabolism of skeletal muscle. Exercise training can, in part, reverse these peripheral alterations, improve exercise capacity, and alleviate fatigue.
疲劳是慢性心力衰竭患者的一个突出症状，限制了身体活动并损害生活质量。尽管其潜在机制尚未明确，但与心力衰竭外周适应相关的改变似乎起着重要作用，包括运动期间外周灌注不同程度受损、骨骼肌氧化能力降低、肌肉力量受损，以及可能与骨骼肌代谢改变相关的反射机制。运动训练可以部分逆转这些外周改变，提高运动能力，并减轻疲劳。
