通过碘(III)介导的酮与腈的反应合成高取代恶唑。
Synthesis of highly substituted oxazoles through iodine(III)-mediated reactions of ketones with nitriles.
机构信息
Laboratory of Organic Reaction Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan.
出版信息
Molecules. 2012 Sep 13;17(9):11046-55. doi: 10.3390/molecules170911046.
Abstract
In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf₂NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions.
摘要
在三氟甲磺酸（TfOH）或双（三氟甲烷磺酰基）亚胺（Tf₂NH）的存在下，碘苯（PhI=O）能够高效地促进二羰基化合物以及单羰基化合物与腈的反应，在温和条件下以一步反应得到 2,4-二取代和 2,4,5-三取代恶唑。
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