一种新型的偕二氟环丙基酮与腈的反应，生成 2-氟吡咯。
A novel reaction of gem-difluorocyclopropyl ketones with nitriles leading to 2-fluoropyrroles.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
出版信息
Chem Commun (Camb). 2013 Oct 28;49(84):9833-5. doi: 10.1039/c3cc45456h.
PMID:24030730
Abstract
The CF3SO3H-promoted ring opening of gem-difluorocyclopropyl ketones prefers to undergo proximal bond cleavage and the subsequent cyclization with nitriles occurred smoothly to give 2-fluoropyrroles.
摘要
CF3SO3H 促进的偕二氟环丙基酮的开环反应优先发生近位键断裂，随后与腈发生的环化反应顺利进行，得到 2-氟吡咯。
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