Pinto P C, Hu E, Bernstein-Singer M, Pinter-Brown L, Govindarajan S
Department of Medicine, Los Angeles County University of Southern California Medical Center.
Cancer. 1990 Feb 15;65(4):878-84. doi: 10.1002/1097-0142(19900215)65:4<878::aid-cncr2820650409>3.0.co;2-k.
Five patients with lymphoproliferative malignancies and chronic hepatitis B suffered severe acute hepatic injury after the withdrawal of multiagent chemotherapy that included high-dose corticosteroid. Four patients died of hepatic failure, three of whom received corticosteroid as treatment for the hepatic injury. We believe that the cause of this entity is massive immune-associated cytolysis of hepatitis B virus infected hepatocytes occurring after a period of immunosuppression and increased viral replication. The literature regarding this complication of chemotherapy and its pathophysiology is reviewed.
五例患有淋巴增殖性恶性肿瘤且慢性乙型肝炎的患者在停用包含大剂量皮质类固醇的多药联合化疗后，出现了严重的急性肝损伤。四名患者死于肝衰竭，其中三名接受了皮质类固醇治疗肝损伤。我们认为，这种情况的病因是在一段免疫抑制及病毒复制增加之后，乙肝病毒感染的肝细胞发生了大量免疫相关的细胞溶解。本文对有关化疗这一并发症及其病理生理学的文献进行了综述。
