Sato T, Kato J, Kawanishi J, Kogawa K, Ohya M, Sakamaki S, Niitsu Y
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
J Gastroenterol. 1997 Oct;32(5):668-71. doi: 10.1007/BF02934119.
A 43-year-old Japanese man who was positive for hepatitis B surface (HBs) antigen and HB e antibody, underwent chemotherapy for non-Hodgkin's lymphoma. After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-alpha, glucagon-insulin therapy, and plasma exchange. Mutations were detected in codons 97, 100, 129, and 131 of the core region of HBV. The peptide encoded from the core region including such mutations possibly had greater antigenicity to induce cytotoxic T cell activity in the host. Core region mutations may be a crucial cause of the acute exacerbation of hepatitis B seen after chemotherapy.
一名43岁的日本男性，乙肝表面抗原（HBs）和乙肝e抗体呈阳性，因非霍奇金淋巴瘤接受化疗。化疗后，由于乙肝病毒（HBV）再激活，他患上了急性肝炎加重。通过α干扰素、胰高血糖素 - 胰岛素疗法和血浆置换实现了康复。在HBV核心区域的第97、100、129和131密码子中检测到突变。包含此类突变的核心区域编码的肽可能具有更强的抗原性，从而在宿主体内诱导细胞毒性T细胞活性。核心区域突变可能是化疗后出现的乙肝急性加重的关键原因。
