吖啶环加成与 3-氧化吡啶鎓物种。
Aryne cycloaddition with 3-oxidopyridinium species.
机构信息
Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Jinming Campus, Kaifeng, Henan 475004, PR China.
出版信息
Org Biomol Chem. 2012 Dec 7;10(45):8975-84. doi: 10.1039/c2ob26519b. Epub 2012 Sep 13.
PMID:22976849
Abstract
The [3 + 2] cycloaddition of arynes with 3-oxidopyridinium species is examined using the Kobayashi benzyne precursor. The reaction affords a bicyclo[3.2.1] skeleton under mild conditions. A [7 + 2] cycloaddition mode with a subsequent pyridine ring-opening event has also been observed.
摘要
使用小林苯炔前体考察了芳炔与 3-氧化吡啶鎓物种的 [3 + 2]环加成反应。该反应在温和条件下生成双环[3.2.1]骨架。还观察到了随后吡啶环开环的 [7 + 2]环加成模式。
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