区域和对映选择性钴催化炔烃与环烯酮的还原[3+2]环加成反应：构建双环叔醇的新途径。
Regio- and enantioselective cobalt-catalyzed reductive [3+2] cycloaddition reaction of alkynes with cyclic enones: a route to bicyclic tertiary alcohols.
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
出版信息
Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10592-5. doi: 10.1002/anie.201205115. Epub 2012 Sep 13.
PMID:22976938
Abstract
Round and round: An unusual cobalt-catalyzed regio- and enantioselective reductive [3+2] cycloaddition of cyclic enones with alkynes affording bicyclic tertiary alcohols is described. A possible mechanism involving the formation of a cobaltacyclopentene intermediate is proposed.
摘要
循环往复
一种钴催化的环状烯酮与炔烃的区域和对映选择性还原[3+2]环加成反应，生成双环叔醇，这是一种不常见的反应。本文提出了一种可能的反应机理，涉及钴环戊烯中间体的形成。
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