纤维超分子血红素蛋白组装体与合成血红素二聚体和脱辅基血红素二聚体相连。
Fibrous supramolecular hemoprotein assemblies connected with synthetic heme dimer and apohemoprotein dimer.
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Chem Biodivers. 2012 Sep;9(9):1684-92. doi: 10.1002/cbdv.201100434.
PMID:22976961
Abstract
Supramolecular hemoprotein assemblies via heme-heme pocket interaction were prepared by synthetic heme dimers containing a linker with charged amino acids and apohemoprotein disulfide dimers. The mixture of the negatively charged heme dimer and the apomyoglobin dimer provides heterotropic fibrous hemoprotein assemblies, which were characterized by size-exclusion chromatography (SEC) and atomic force microscopy (AFM).
摘要
通过含有带电荷氨基酸的连接子的合成血红素二聚体和脱辅基血红素二硫键二聚体制备了通过血红素-血红素口袋相互作用的超分子血红蛋白组装体。带负电荷的血红素二聚体和去辅基肌红蛋白二聚体的混合物提供了异源纤维状血红蛋白组装体，其通过尺寸排阻色谱（SEC）和原子力显微镜（AFM）进行了表征。
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