Fibrous supramolecular hemoprotein assemblies connected with synthetic heme dimer and apohemoprotein dimer.

Supramolecular hemoprotein assemblies via heme-heme pocket interaction were prepared by synthetic heme dimers containing a linker with charged amino acids and apohemoprotein disulfide dimers. The mixture of the negatively charged heme dimer and the apomyoglobin dimer provides heterotropic fibrous hemoprotein assemblies, which were characterized by size-exclusion chromatography (SEC) and atomic force microscopy (AFM).