抗癌基因治疗中的细胞靶向
Cell targeting in anti-cancer gene therapy.
作者信息
Lila Mohd Azmi Mohd, Siew John Shia Kwong, Zakaria Hayati, Saad Suria Mohd, Ni Lim Shen, Abdullah Jafri Malin
机构信息
Institute of Bioscience, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Malaysia.
出版信息
Malays J Med Sci. 2004 Jan;11(1):9-23.
Abstract
Gene therapy is a promising approach towards cancer treatment. The main aim of the therapy is to destroy cancer cells, usually by apoptotic mechanisms, and preserving others. However, its application has been hindered by many factors including poor cellular uptake, non-specific cell targeting and undesirable interferences with other genes or gene products. A variety of strategies exist to improve cellular uptake efficiency of gene-based therapies. This paper highlights advancements in gene therapy research and its application in relation to anti-cancer treatment.
摘要
基因治疗是一种很有前景的癌症治疗方法。该疗法的主要目的是通常通过凋亡机制来破坏癌细胞，并保护其他细胞。然而，其应用受到许多因素的阻碍，包括细胞摄取不佳、非特异性细胞靶向以及对其他基因或基因产物的不良干扰。存在多种策略来提高基于基因的疗法的细胞摄取效率。本文重点介绍了基因治疗研究的进展及其在抗癌治疗方面的应用。
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