RNA干扰：自然厌恶双链。
RNAi: nature abhors a double-strand.
作者信息
Hutvágner György, Zamore Phillip D
机构信息
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA.
出版信息
Curr Opin Genet Dev. 2002 Apr;12(2):225-32. doi: 10.1016/s0959-437x(02)00290-3.
Abstract
In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.
摘要
在诸如线虫、锥虫、植物和真菌等多种多样的生物体中，双链RNA会引发同源mRNA的降解，这一现象被称为RNA干扰。RNA干扰始于双链RNA转变为小RNA，这些小RNA随后引导一种蛋白核酸酶去破坏它们的mRNA靶标。
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