Perraud Aurélie, Nouaille Michelle, Akil Hussein, Petit Daniel, Labrousse François, Jauberteau Marie-Odile, Mathonnet Muriel
EA 3842, Homéostasie Cellulaire et Pathologies, Faculté de Médecine et de Pharmacie and.
Exp Ther Med. 2011 May;2(3):491-497. doi: 10.3892/etm.2011.242. Epub 2011 Mar 21.
The status of the three retinoic acid receptors (RARs) α, β and γ in human colorectal cancer (CRC) has not as yet been examined. RARs are in part responsible for the actions of the retinoids (vitamin A and its derivatives), which are essential for human health and survival due to their extensive involvement in numerous cellular processes, in particular in epithelial morphology. The present study examined the expression of the three RARs in CRC using immunohistochemical analysis of paraffin-embedded tissue sections. RAR expression in tumor (T) and adjacent non-tumor (NT) specimens from stage I (n=6), stage II (n=34), stage III (n=26) and stage IV (n=14) CRC patients was compared with that in normal mucous membranes (n=10) from control individuals. The findings were correlated with tumor grade, treatment response (progression during treatment, remission, chemoresistance) and survival as clinicopathological parameters. RARα and γ expression was decreased with CRC stage in the T tissues (P=0.016 and P=0.052, respectively), suggesting that they may be used as predictive markers. RARβ expression in the NT tissues was associated with a more favorable prognosis (P=0.04). These results provide important information on the tumor microenvironment (the area adjacent to tumor cells).
三种维甲酸受体（RAR）α、β和γ在人类结直肠癌（CRC）中的状态尚未得到研究。RAR部分介导类视黄醇（维生素A及其衍生物）的作用，类视黄醇对人类健康和生存至关重要，因为它们广泛参与众多细胞过程，尤其是上皮形态形成。本研究通过对石蜡包埋组织切片进行免疫组化分析，检测了CRC中三种RAR的表达。将I期（n = 6）、II期（n = 34）、III期（n = 26）和IV期（n = 14）CRC患者的肿瘤（T）和相邻非肿瘤（NT）标本中的RAR表达与对照个体的正常黏膜（n = 10）中的表达进行比较。研究结果与肿瘤分级、治疗反应（治疗期间进展、缓解、化疗耐药）和生存等临床病理参数相关。在T组织中，RARα和γ的表达随CRC分期降低（分别为P = 0.016和P = 0.052），表明它们可用作预测标志物。NT组织中RARβ的表达与更有利的预后相关（P = 0.04）。这些结果提供了关于肿瘤微环境（肿瘤细胞相邻区域）的重要信息。
