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肝细胞癌组织的血管生成取决于其分化程度。

Vascularization of hepatocellular carcinoma tissue depends on its differentiation degree.

作者信息

Shchyogolev A I, Dubova E A, Tumanova U N

机构信息

V. I. Kulakov Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia. ashegolev@oparina4ru

出版信息

Bull Exp Biol Med. 2012 Aug;153(4):490-4. doi: 10.1007/s10517-012-1749-x.

DOI:10.1007/s10517-012-1749-x
PMID:22977853
Abstract

Quantitative characteristics of vessels in hepatocellular carcinoma and adjacent liver tissue were studied by morphometric methods after immunohistochemical staining for CD34 and CD105. The number of immunopositive vessels decreased with reduction of tumor histological differentiation degree.

摘要

在对CD34和CD105进行免疫组织化学染色后,采用形态计量学方法研究肝细胞癌及癌旁肝组织中血管的定量特征。免疫阳性血管数量随肿瘤组织学分化程度降低而减少。

相似文献

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Vascularization of hepatocellular carcinoma tissue depends on its differentiation degree.肝细胞癌组织的血管生成取决于其分化程度。
Bull Exp Biol Med. 2012 Aug;153(4):490-4. doi: 10.1007/s10517-012-1749-x.
2
[Tumor microvascular density detected by anti-CD105 and anti-CD34 in hepatocellular carcinoma patients and its predictive value of tumor recurrence after liver transplantation].[抗CD105和抗CD34检测肝细胞癌患者肿瘤微血管密度及其对肝移植后肿瘤复发的预测价值]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Sep;41(5):818-21.
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Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver.内皮糖蛋白(CD105)在肝细胞癌及其癌旁非肿瘤性肝组织中的表达的临床病理及预后意义
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Microvascular density of regenerative nodule to small hepatocellular carcinoma by automated analysis using CD105 and CD34 immunoexpression.利用CD105和CD34免疫表达通过自动分析检测再生结节至小肝细胞癌的微血管密度
BMC Cancer. 2014 Feb 7;14:72. doi: 10.1186/1471-2407-14-72.
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Endoglin (CD105) expression in angiogenesis of primary hepatocellular carcinomas: analysis using tissue microarrays and comparisons with CD34 and VEGF.内皮糖蛋白(CD105)在原发性肝细胞癌血管生成中的表达:应用组织芯片分析并与CD34和血管内皮生长因子比较
Ann Clin Lab Sci. 2007 Winter;37(1):39-48.
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Morphometric and immunohistochemical study of angiogenic marker expressions in invasive ductal carcinoma of human breast.人乳腺浸润性导管癌中血管生成标志物表达的形态计量学和免疫组织化学研究
Folia Morphol (Warsz). 2009 Aug;68(3):144-55.
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Transforming growth factor-beta1 and CD105 promote the migration of hepatocellular carcinoma-derived endothelium.转化生长因子-β1和CD105促进肝癌来源内皮细胞的迁移。
Cancer Res. 2008 Oct 15;68(20):8626-34. doi: 10.1158/0008-5472.CAN-08-1218.
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Human hepatocellular carcinoma tumor-derived endothelial cells manifest increased angiogenesis capability and drug resistance compared with normal endothelial cells.与正常内皮细胞相比,人肝细胞癌肿瘤来源的内皮细胞表现出更强的血管生成能力和耐药性。
Clin Cancer Res. 2009 Aug 1;15(15):4838-46. doi: 10.1158/1078-0432.CCR-08-2780. Epub 2009 Jul 28.
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Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry.
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The mobilization, recruitment and contribution of bone marrow-derived endothelial progenitor cells to the tumor neovascularization occur at an early stage and throughout the entire process of hepatocellular carcinoma growth.骨髓源性内皮祖细胞的动员、募集和贡献发生在肝癌生长的早期,并贯穿整个过程。
Oncol Rep. 2012 Oct;28(4):1217-24. doi: 10.3892/or.2012.1944. Epub 2012 Jul 31.

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Int J Clin Exp Med. 2014 Nov 15;7(11):3859-69. eCollection 2014.