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[不育男性精液中的支原体和抗衣原体抗体及其与精液质量和男性附属性腺标志物的关系]

[Mycoplasmas and antibodies anti-Chlamydia in semen of infertile men and their relationship with seminal quality and markers of male accessory sex glands].

作者信息

Lozano-Hernández Ricardo, Vivas-Acevedo Giovanny, Muñoz de Vera María Gladys

机构信息

Centro Diagnóstico de Infertilidad y Enfermedades Genéticas (CEDIEG), Facultad de Farmacia y Bioanálisis, Universidad de Los Andes, Mérida, Venezuela.

出版信息

Invest Clin. 2012 Jun;53(2):138-47.

Abstract

Male infertility may be due to inflammation or infection of the genital tract among other causes. Male accessory sex glands and sperm function may also be involved in the problem of infertility. This study tries to associate the most frequent bacteria in semen of infertile men including Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum with the seminal characteristics and levels of fructose, citric acid and alpha-neutral glucosidase as markers of the accessory glands. Detection of antibodies anti Chlamydia trachomatis indicated that it was the most prevalent germ. Antibodies (Ab) anti-Chlamydia, Mycoplasma hominis and Ureaplasma urealyticum were associated with a decrease of the glandular markers fructose and alpha-neutral glucosidase. On the other hand, there were increased pH and leukocytospermia in men positive for antibodies anti-Chlamydia. Microbiological and biochemical evaluation of semen could orient more about the spread of infection and allow for the selection of the most effective therapy. We find that microbiological and glandular accessory markers assessments in semen are important to diagnose and to treat infections.

摘要

男性不育可能是由于生殖道炎症或感染等多种原因引起的。男性附属性腺和精子功能也可能与不育问题有关。本研究试图将不育男性精液中最常见的细菌,包括沙眼衣原体、人型支原体和解脲脲原体,与附属腺标志物果糖、柠檬酸和α-中性葡萄糖苷酶的精液特征及水平联系起来。抗沙眼衣原体抗体检测表明它是最普遍的病原体。抗沙眼衣原体、人型支原体和解脲脲原体抗体(Ab)与腺标志物果糖和α-中性葡萄糖苷酶的降低有关。另一方面,抗衣原体抗体呈阳性的男性精液pH值升高且出现白细胞精子症。精液的微生物学和生化评估可以更准确地了解感染的传播情况,并有助于选择最有效的治疗方法。我们发现精液中的微生物学和附属腺标志物评估对于诊断和治疗感染很重要。

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