在极度高催乳素血症中促肾上腺皮质激素对肾上腺雄激素刺激的缺乏。

Lack of adrenal androgen stimulation by ACTH in extreme hyperprolactinemia.

作者信息

Parker L, Perrigo V, Skowsky R

出版信息

Arch Androl. 1979 Nov;3(3):259-61. doi: 10.3109/01485017908988413.

Abstract

Acute and prolonged alpha 1-24 corticotropin stimulation was performed on a treated chromophobe adenoma patient with partial ACTH deficiency and extreme hyperprolactinemia. Cortisol and aldosterone stimulated normally. However, the basal concentrations of androstenedione (A) and dehydroepiandrosterone (DHA) were low, and that of DHA-sulfate (DHAS) was undetectable. Furthermore, A and DHA did not stimulate normally, and DHAS did not stimulate at all. It has been claimed that adrenal androgen production is increased in hyperprolactinemia. However, the inability of prolactin (Prl) to maintain adrenal androgen (AA) secretion, with and without added ACTH, is demonstrated in this patient.

摘要

对一名患有部分促肾上腺皮质激素（ACTH）缺乏和极度高催乳素血症的经治疗的嫌色细胞瘤患者进行了急性和长期的α1-24促肾上腺皮质激素刺激。皮质醇和醛固酮刺激正常。然而，雄烯二酮（A）和脱氢表雄酮（DHA）的基础浓度较低，且硫酸脱氢表雄酮（DHAS）无法检测到。此外，A和DHA刺激不正常，而DHAS根本不产生刺激。有人声称高催乳素血症中肾上腺雄激素生成增加。然而，该患者证明，无论有无添加ACTH，催乳素（Prl）均无法维持肾上腺雄激素（AA）分泌。