Massucchetti C, Biffignandi P, Gentile L, Molinatti G M
Boll Soc Ital Biol Sper. 1983 Oct 30;59(10):1423-8.
Chemical manipulations of the native ACTH (1-39) molecule led to the synthesis of a newly characterized compound which shows several interesting features, such as an enhanced half-life, an increased resistance against enzymic degradation and lower immunogenic activity. This study aimed at comparing the adrenal steroidogenetic response of the 1-17 analogue and of the other commercially available synthetic ACTH (1-24). Results suggest that ACTH 1-17 has a more pronounced and prolonged activity, which is confined to glico- and mineralocorticoid secretion.
对天然促肾上腺皮质激素（1-39）分子进行化学操作，合成了一种具有新特性的化合物，该化合物具有几个有趣的特征，如半衰期延长、抗酶解能力增强和免疫原活性降低。本研究旨在比较1-17类似物与其他市售合成促肾上腺皮质激素（1-24）对肾上腺类固醇生成的反应。结果表明，促肾上腺皮质激素1-17具有更显著和持久的活性，且这种活性仅限于糖皮质激素和盐皮质激素的分泌。
