Marcetić Mirjana, Bozić Dragana, Milenković Marina, Lakusić Branislava, Kovacević Nada
Department of Pharmacognosy, University of Belgrade-Faculty of Pharmacy, V. Stepe 450, 11221 Belgrade, Serbia.
Nat Prod Commun. 2012 Aug;7(8):1091-4.
The chemical composition and antimicrobial activity of the essential oil of the Balkan endemic species Seseli rigidum Waldst. & Kit. (Apiaceae) was investigated. The monoterpene alpha-pinene was predominant in the volatile oil from aerial parts (57.4%) and fruit (23.3%). In the essential oil of the aerial parts limonene (6.7%), camphene (5.8%) and sabinene (5.5%) were also present in high amounts, and in the fruit oil, beta-phellandrene (17.4%) and sabinene (12.9%). On the contrary, the root essential oil was composed almost entirely of the polyacetylene falcarinol (88.8%). The antimicrobial activity of the root essential oil was significant against Staphylococcus aureus, S. epidermidis, Micrococcus luteus and Enterococcus faecalis (MICs 6.25-25.00 microg/mL). Volatile constituents from the root strongly inhibited the growth of methicillin-resistant strains of S. aureus (MICs 6.25-50.00 microg/mL). Anti-staphylococcal activity can be attributed to the main volatile constituent ofS. rigidum root, falcarinol.
对巴尔干地区特有物种硬叶邪蒿（Seseli rigidum Waldst. & Kit.，伞形科）精油的化学成分和抗菌活性进行了研究。单萜α-蒎烯在地上部分挥发油（57.4%）和果实挥发油（23.3%）中占主导地位。地上部分精油中柠檬烯（6.7%）、莰烯（5.8%）和桧烯（5.5%）含量也较高，果实精油中β-水芹烯（17.4%）和桧烯（12.9%）含量较高。相反，根部精油几乎完全由聚乙炔类的镰叶芹醇（88.8%）组成。根部精油对金黄色葡萄球菌、表皮葡萄球菌、藤黄微球菌和粪肠球菌具有显著抗菌活性（最低抑菌浓度为6.25 - 25.00微克/毫升）。根部挥发性成分强烈抑制耐甲氧西林金黄色葡萄球菌菌株的生长（最低抑菌浓度为6.25 - 50.00微克/毫升）。抗葡萄球菌活性可归因于硬叶邪蒿根部的主要挥发性成分镰叶芹醇。
