Popović Visnja, Petrović Silvana, Pavlović Milica, Milenković Marina, Couladis Maria, Tzakou Olga, Duraki Semija, Niketić Marjan
Institute of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, V. Stepe 450, 11221 Belgrade, Serbia.
Nat Prod Commun. 2010 Feb;5(2):307-10.
The composition and antimicrobial activity of the essential oil from the underground parts (roots and rhizomes) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The pale blue essential oil, obtained by hydrodistillation, was analyzed by GC and GC-MS. Forty-three compounds were identified (94.3% of total oil). The main constituent, beside alpha-pinene (31.6%) was alpha-bisabolol (30.9%), so this oil may be a novel potential natural source of this sesquiterpene alcohol. The antimicrobial activity was tested using the microdilution method against Gram (+) bacteria (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis), Gram (-) bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli), and two strains of yeast (Candida albicans). L. zernyi oil showed significant antibacterial activity against S. epidermidis, S. aureus and M. luteus, but lower activities against the other tested strains.
对泽尔尼岩风（伞形科）地下部分（根和根茎）的精油成分及抗菌活性进行了研究。通过水蒸馏法获得淡蓝色精油，并采用气相色谱（GC）和气相色谱-质谱联用（GC-MS）进行分析。共鉴定出43种化合物（占总油量的94.3%）。除α-蒎烯（31.6%）外，主要成分是α-红没药醇（30.9%），因此这种精油可能是这种倍半萜醇的新型潜在天然来源。采用微量稀释法对革兰氏阳性菌（金黄色葡萄球菌、表皮葡萄球菌、藤黄微球菌、粪肠球菌）、革兰氏阴性菌（铜绿假单胞菌、肺炎克雷伯菌、大肠杆菌）和两种酵母菌株（白色念珠菌）进行抗菌活性测试。泽尔尼岩风精油对表皮葡萄球菌、金黄色葡萄球菌和藤黄微球菌显示出显著的抗菌活性，但对其他测试菌株的活性较低。
