Moskowitz W B, Mosteller M, Schieken R M, Bossano R, Hewitt J K, Bodurtha J N, Segrest J P
Children's Medical Center, Department of Human Genetics of the Medical College of Virginia, Richmond.
Circulation. 1990 Feb;81(2):586-92. doi: 10.1161/01.cir.81.2.586.
We investigated the cardiovascular effects of lifelong passive cigarette smoke exposure in preadolescent children and examined the following questions: 1) Is systemic oxygen transport altered? 2) Are coronary heart disease risk factors adversely affected? We recruited 216 families from the MCV Twin Study; 105 had at least one smoking parent. Serum thiocyanate and cotinine levels were used as measures of smoke exposure in the children and thiocyanate was proportional to the number of parental cigarettes smoked each day (p = 0.0001). Paternal smoking had no effect on these measures. Whole blood 2,3-diphosphoglycerate was higher in smoke-exposed than unexposed children (p less than 0.01) and was related to the thiocyanate level (p less than 0.02). High density lipoprotein (HDL) cholesterol was lower in passive smoking children (p less than 0.05); the HDL2 subfraction was reduced in passive smoking boys, while the HDL3 subfraction was reduced in passive smoking girls. Significant adverse alterations in systemic oxygen transport and lipoprotein profiles are already present in preadolescent children exposed to long-term passive cigarette smoke, primarily from maternal smoke. Children with long-term exposure to passive smoke may be at elevated risk for the development of premature coronary heart disease.
我们研究了青春期前儿童终身被动接触香烟烟雾对心血管的影响，并探讨了以下问题：1）全身氧转运是否改变？2）冠心病危险因素是否受到不利影响？我们从MCV双胞胎研究中招募了216个家庭；其中105个家庭至少有一位吸烟的家长。血清硫氰酸盐和可替宁水平被用作衡量儿童接触烟雾的指标，硫氰酸盐与家长每天吸烟的数量成正比（p = 0.0001）。父亲吸烟对这些指标没有影响。接触烟雾的儿童全血2,3-二磷酸甘油酸水平高于未接触烟雾的儿童（p < 0.01），且与硫氰酸盐水平相关（p < 0.02）。被动吸烟儿童的高密度脂蛋白（HDL）胆固醇水平较低（p < 0.05）；被动吸烟男孩的HDL2亚组分降低，而被动吸烟女孩的HDL3亚组分降低。长期被动接触香烟烟雾的青春期前儿童，主要是接触母亲的烟雾，全身氧转运和脂蛋白谱已经出现显著的不利改变。长期接触被动烟雾的儿童患早发性冠心病的风险可能会升高。
