Hall N J, Wynne C D L
Department of Psychology, University of Florida, Gainesville, FL, USA.
Genes Brain Behav. 2012 Nov;11(8):889-902. doi: 10.1111/j.1601-183X.2012.00851.x. Epub 2012 Oct 12.
We review a range of studies on the genetic contribution to behavior in canid species. We begin by identifying factors that make canids a promising model in behavioral genetics and proceed to review research over the last decade that has used canids to identify genetic contributions to behavior. We first review studies that have selectively bred dogs to identify genetic contributions to behavior and then review studies that estimate heritability from populations of non-laboratory bred dogs. We subsequently review studies that used molecular genetics to identify gene-behavior associations and note associations that have been uncovered. We then note challenges in canid behavioral genetics research that require further consideration. We finish by suggesting alternative phenotyping methods and identify areas in which canids may have as yet unexploited advantages, such as in gene-environment interaction studies where genetic factors are found to moderate the effects of environmental variables.
我们回顾了一系列关于犬科动物行为遗传贡献的研究。我们首先确定使犬科动物成为行为遗传学中有前景模型的因素，然后回顾过去十年中利用犬科动物来确定行为遗传贡献的研究。我们首先回顾通过选择性培育狗来确定行为遗传贡献的研究，然后回顾从非实验室培育的狗群体中估计遗传力的研究。随后，我们回顾使用分子遗传学来确定基因与行为关联的研究，并指出已发现的关联。然后，我们指出犬科动物行为遗传学研究中需要进一步考虑的挑战。我们最后提出替代表型分析方法，并确定犬科动物可能具有尚未开发优势的领域，例如在基因-环境相互作用研究中，发现遗传因素可调节环境变量的影响。
