Montreal Neurological Institute, 3801 University St, Montreal, Canada QC H3A 2B4.
Epilepsy Behav. 2012 Sep;25(1):42-9. doi: 10.1016/j.yebeh.2012.07.003. Epub 2012 Aug 17.
Material-specific memory impairments are a well-established consequence of unilateral medial temporal lobe damage. We used fMRI to investigate encoding and recognition of verbal and nonverbal stimuli using adaptations of tasks used successfully in clinical evaluations of patients with temporal lobe epilepsy (TLE). We studied two patient groups, one with left TLE and one with right TLE, and one group of healthy subjects. Results from the healthy subjects indicated that initial and delayed recognition trials of the verbal task activated the left medial temporal lobe, and the same tasks of the nonverbal task activated the right, confirming the sensitivity to laterality of our clinical tasks. Patients tended to use the opposite hippocampus, but often the parahippocampal gyrus on the same side, compared to the healthy subjects. Since our patients and the healthy groups performed similarly on the memory tasks, we conclude that the patients' activation patterns represent an effective adaptation to the presence of an unhealthy hippocampus.
特定材料记忆损伤是单侧内侧颞叶损伤的公认后果。我们使用 fMRI 研究了言语和非言语刺激的编码和识别，使用了在颞叶癫痫 (TLE) 患者临床评估中成功使用的任务的改编。我们研究了两组患者，一组左颞叶癫痫，一组右颞叶癫痫，一组健康受试者。健康受试者的结果表明，言语任务的初始和延迟识别试验激活了左侧内侧颞叶，而相同的非言语任务的任务激活了右侧，这证实了我们的临床任务对侧化的敏感性。与健康受试者相比，患者往往使用相反的海马体，但通常是同侧的海马旁回。由于我们的患者和健康组在记忆任务上表现相似，我们得出结论，患者的激活模式代表了对不健康海马体存在的有效适应。
