致病的孔形成蛋白：功能和宿主反应。

Pathogenic pore-forming proteins: function and host response.

机构信息

Ecole Polytechnique Fédérale de Lausanne, Global Health Institute, Station 15, CH-1015 Lausanne, Switzerland.

出版信息

Cell Host Microbe. 2012 Sep 13;12(3):266-75. doi: 10.1016/j.chom.2012.08.005.

DOI:10.1016/j.chom.2012.08.005

Abstract

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.

摘要

所有生物界的生物都会产生形成孔道的蛋白质，其中研究得最透彻的是细菌来源的蛋白质。过去十年的研究表明，这些蛋白质形成的通道具有多样性，因此会对靶细胞膜通透性和后续的细胞结果产生不同的影响。由于孔道引起的离子平衡变化会产生多种下游效应，因此对这些毒素的反应也非常多样。确定形成孔道毒素的次级效应对于理解它们在感染中的作用至关重要。