Knowles N J, Buckley L S, Pereira H G
Arch Virol. 1979;62(3):201-8. doi: 10.1007/BF01317552.
Porcine enteroviruses isolated in the United Kingdom between 1972 and 1976 were compared with the 8 serotypes previously described and with human coxsackie B virus types 1 to 6 for ability to grow in different cell lines. This allowed the classification of all strains into 3 broad groups according to type of cytopathic effect in IBRS-2 cells and further subdivision on the basis of production of cytopathic effect in BHK 21, HeLa and VERO cells. None of the porcine enterovirus strains was neutralized by antisera to human enteroviruses (Lim Benyesh-Melnick Pools) with the exception of swine vesicular disease virus, which was neutralised by coxsackie B5 antiserum. Antisera prepared either in gnotobiotic pigs or in guinea pigs against the 8 porcine enterovirus serotypes failed to neutralize 9 isolates which could be classified into 3 new serotypes, for which Nos. 9, 10 and 11 are proposed. Guinea pig sera could be used as an alternative to gnotobiotic pig sera for type differentiation.
将1972年至1976年间在英国分离出的猪肠道病毒与先前描述的8种血清型以及人柯萨奇B病毒1至6型进行比较，以研究它们在不同细胞系中的生长能力。根据在IBRS - 2细胞中的细胞病变效应类型，可将所有菌株分为3大类，并根据在BHK 21、HeLa和VERO细胞中产生细胞病变效应的情况进一步细分。除猪水疱病病毒可被柯萨奇B5抗血清中和外，没有一种猪肠道病毒菌株能被人肠道病毒抗血清（林·贝涅什 - 梅尔尼克混合血清）中和。用无菌猪或豚鼠制备的针对8种猪肠道病毒血清型的抗血清，无法中和9株可被分类为3种新血清型的分离株，建议将其分别命名为9型、10型和11型。豚鼠血清可替代无菌猪血清用于血清型鉴别。
