循证医学实践：过敏性鼻炎的舌下免疫疗法

Evidence-based practice: sublingual immunotherapy for allergic rhinitis.

作者信息

Wise Sarah K, Schlosser Rodney J

机构信息

Otolaryngology-Head and Neck Surgery, Emory University, 550 Peachtree Street, MOT 9th Floor, Atlanta, GA 30308, USA.

出版信息

Otolaryngol Clin North Am. 2012 Oct;45(5):1045-54. doi: 10.1016/j.otc.2012.06.008. Epub 2012 Jul 24.

DOI:10.1016/j.otc.2012.06.008

PMID:22980684

Abstract

In this article, the authors review the current evidence regarding the public health and economic impact of allergic rhinitis. Diagnostic methods for allergic disease are discussed as well as certain nuances of allergy skin testing protocols. In addition, the evidence supporting sublingual immunotherapy (SLIT) for allergic rhinitis is reviewed, with subsequent attention to certain subgroups, such as adults and children, seasonal versus perennial allergens, and SLIT efficacy for individual antigens. The authors consider the evidence supporting appropriate SLIT dosing as well as the existing data on SLIT safety.

摘要

在本文中，作者回顾了关于变应性鼻炎对公众健康和经济影响的现有证据。讨论了变应性疾病的诊断方法以及变应性皮肤试验方案的某些细微差别。此外，还回顾了支持舌下免疫疗法（SLIT）治疗变应性鼻炎的证据，随后关注了某些亚组，如成人和儿童、季节性与常年性变应原，以及SLIT对个体抗原的疗效。作者考虑了支持适当SLIT剂量的证据以及SLIT安全性的现有数据。