Food and Drug Toxicology Research Centre, National Institute of Nutrition (ICMR), PO - Jamai Osmania, Hyderabad 500 007, India.
Food Chem. 2012 Dec 15;135(4):2954-9. doi: 10.1016/j.foodchem.2012.06.116. Epub 2012 Jul 14.
Ginger is an important medicinal herb has numerous bioactive components and is used in the management, control and/or treatment of diseases including diabetes mellitus. The present study was undertaken to see the dose-response effect of ginger and evaluate the possible protective effects of dietary ginger on oxidative stress and genotoxicity induced by streptozotocin (STZ) diabetic rats. Inbred male Wistar/NIN rats of 8-9 weeks old were treated with 30 mg/kg of STZ. Rats were divided into different groups of control, diabetic non-treated, and diabetic treated with ginger powder at 0.5%, 1% and 5% respectively. After feeding for a month, blood and tissues were collected to see the effect of ginger on antioxidant status, DNA damage and bone marrow genotoxicity. In this study ginger exerted a protective effect against STZ-induced diabetes by modulating antioxidant enzymes and glutathione and down regulating lipid and protein oxidation and inhibition in genotoxicity in a dose-response manner.
姜是一种重要的药用草本植物，具有多种生物活性成分，可用于管理、控制和/或治疗包括糖尿病在内的疾病。本研究旨在观察姜的剂量反应效应，并评估膳食姜对链脲佐菌素（STZ）诱导的糖尿病大鼠氧化应激和遗传毒性的可能保护作用。将 8-9 周龄的近交雄性 Wistar/NIN 大鼠用 30mg/kg 的 STZ 处理。将大鼠分为对照组、未治疗糖尿病组和分别用 0.5%、1%和 5%姜粉治疗的糖尿病组。喂养一个月后，收集血液和组织，观察姜对抗氧化状态、DNA 损伤和骨髓遗传毒性的影响。在这项研究中，姜通过调节抗氧化酶和谷胱甘肽，以及下调脂质和蛋白质氧化和抑制遗传毒性，以剂量反应的方式对 STZ 诱导的糖尿病发挥了保护作用。
