Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Korea.
Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Korea.
Int J Environ Res Public Health. 2021 Jan 13;18(2):631. doi: 10.3390/ijerph18020631.
Obesity is characterized by excessive fat accumulation in adipose tissue, which is an active endocrine organ regulating energy metabolism. Ginger () is known to have antioxidant, anti-inflammatory, and antiobesity effects, but the role of ginger in modulating adipocyte metabolism is largely unknown. In this study, we hypothesized that ginger supplementation inhibits high-fat (HF)-diet-mediated obesity. C57BL/6 male mice were randomly assigned to three diets for 7 weeks: low fat (LF, 16% kcal from fat), HF (HF, 60% kcal from fat), or HF with 5% ginger powder in diet (HF + G). The HF diet increased body weight (BW) and BW gain, as well as fasting glucose, total cholesterol, and hepatic lipid levels, compared to the LF diet-fed group. Ginger supplementation significantly improved HF-diet-induced BW gain, hyperglycemia, hypercholesterolemia, and hepatic steatosis without altering food intake. Next, we investigated whether ginger modulates adipocyte remodeling. HF-mediated adipocyte hypertrophy with increased lipogenic levels was significantly improved by ginger supplementation. Furthermore, the HF+G group showed high levels of the fatty-acid oxidation gene, carnitine palmitoyltransferase 1 (CPT1), which was accompanied by a reduction in adipocyte inflammatory gene expression. Taken together, our work demonstrated that ginger supplementation attenuated HF-diet-mediated obesity and adipocyte remodeling in C57BL/6 mice.
肥胖的特征是脂肪组织中脂肪过度积累，脂肪组织是调节能量代谢的活跃内分泌器官。姜（）已知具有抗氧化、抗炎和抗肥胖作用，但姜在调节脂肪细胞代谢中的作用在很大程度上尚不清楚。在这项研究中，我们假设姜补充剂可抑制高脂肪（HF）饮食介导的肥胖。将 C57BL/6 雄性小鼠随机分为三组饮食 7 周：低脂（LF，脂肪提供 16%的热量）、高脂肪（HF，脂肪提供 60%的热量）或高脂肪饮食中添加 5%姜粉（HF+G）。与 LF 饮食喂养组相比，HF 饮食增加了体重（BW）和 BW 增加，以及空腹血糖、总胆固醇和肝脂质水平。姜补充剂可显著改善 HF 饮食引起的 BW 增加、高血糖、高胆固醇血症和肝脂肪变性，而不改变食物摄入。接下来，我们研究了姜是否调节脂肪细胞重塑。HF 介导的脂肪细胞肥大伴有脂肪生成水平增加，姜补充剂可显著改善。此外，HF+G 组表现出高水平的脂肪酸氧化基因肉碱棕榈酰转移酶 1（CPT1），同时脂肪细胞炎症基因表达减少。总之，我们的工作表明，姜补充剂可减轻 C57BL/6 小鼠 HF 饮食介导的肥胖和脂肪细胞重塑。
