Rutgers University, School of Environmental and Biological Sciences, Foran Hall, 59 Dudley Road, New Brunswick, NJ 08901, USA.
Food Chem. 2012 Dec 15;135(4):2994-3002. doi: 10.1016/j.foodchem.2012.06.117. Epub 2012 Jul 14.
Cinnamon has a long history of medicinal use and continues to be valued for its therapeutic potential for improving metabolic disorders such as type 2 diabetes. In this study, a phytochemically-enhanced functional food ingredient that captures water soluble polyphenols from aqueous cinnamon extract (CE) onto a protein rich matrix was developed. CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet induced obese hyperglycemic mice at 300 and 600 mg/kg, respectively. To determine mechanisms of action, rat hepatoma cells were treated with CE and eluates of CDSF at a range of 1-25 μg/ml. CE and eluates of CDSF demonstrated dose-dependent inhibition of hepatic glucose production with significant levels of inhibition at 25 μg/ml. Furthermore, CE decreased the gene expression of two major regulators of hepatic gluconeogenesis, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. The hypoglycemic and insulin-like effects of CE and CDSF may help to ameliorate type 2 diabetes conditions.
肉桂在药用方面有着悠久的历史，并且因其改善代谢紊乱（如 2 型糖尿病）的治疗潜力而备受重视。在这项研究中，开发了一种植物化学增强型功能性食品成分，它将水溶性多酚从水提肉桂提取物（CE）捕获到富含蛋白质的基质上。CE 和富含肉桂多酚的脱脂大豆粉（CDSF）在 300 和 600mg/kg 时分别有效降低饮食诱导肥胖高血糖小鼠的空腹血糖水平。为了确定作用机制，用 CE 和 CDSF 的洗脱液在 1-25μg/ml 的范围内处理大鼠肝癌细胞。CE 和 CDSF 的洗脱液表现出剂量依赖性的肝葡萄糖生成抑制作用，在 25μg/ml 时具有显著的抑制作用。此外，CE 降低了肝糖异生的两个主要调节因子磷酸烯醇丙酮酸羧激酶和葡萄糖-6-磷酸酶的基因表达。CE 和 CDSF 的降血糖和胰岛素样作用可能有助于改善 2 型糖尿病的状况。
