Santos Heitor O, da Silva Guilherme A R
School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.
Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil.
Clin Nutr ESPEN. 2018 Oct;27:1-9. doi: 10.1016/j.clnesp.2018.07.011. Epub 2018 Aug 13.
BACKGROUND & AIMS: Cinnamon is a condiment used in cooking and by some in large quantities as a supplement with purported hypoglycemic and lipid-lowering potential. The current literature review aims to discuss the evidence of cinnamon administration regarding its hypoglycemic and lipid-lowering effects, summarizing clinical recommendations.
Electronic databases including PubMed, Cochrane library, Science Direct and Web of Science were searched with the scientific name of the plant as well as the common name. The search for articles was based on following keywords: "cinnamon diabetes", "cinnamon diabetes type 2", "cinnamon and diabetes type 2", "Cinnamomum aromaticum", "Cinnamomum cassia", "Cinnamomum verum", "Cinnamomum zeylanicum". We carried out inclusion criteria between 2003 and 2018 focusing on human studies.
Concerning glycemic profile, in individuals with type II diabetes mellitus the fasting blood glucose reduced from 12.9 to 52.2 mg/dL and HbA1c from 0.27 to 0.83%, whereas serum insulin decreased in few studies. Research papers ranged from 6 to 17 weeks in duration. The lipid lowering potential, in turn, is most controversial compared to anti-hyperglycemic potential. Also cinnamon administration has been claimed to reduce fat mass and raise serum antioxidants, but the studies used inaccurate methods. Two species are most investigated, C. cassia/aromaticum, and C.zeylanicum/verum.
About 1-6 g of these cinnamon species mainly in powder seems to be an adjunct drug treatment for type 2 diabetes mellitus and other conditions of glycemic impairment. However, more controlled clinical trials are needed.
肉桂是一种用于烹饪的调味品，有些人大量食用肉桂作为补充剂，据称其具有降血糖和降血脂的潜力。本综述旨在讨论服用肉桂对血糖和血脂影响的证据，并总结临床建议。
通过电子数据库，包括PubMed、Cochrane图书馆、Science Direct和Web of Science，使用该植物的学名和常用名进行检索。文章检索基于以下关键词：“肉桂与糖尿病”、“肉桂与2型糖尿病”、“肉桂与2型糖尿病”、“桂皮”、“肉桂”、“锡兰肉桂”、“斯里兰卡肉桂”。我们纳入了2003年至2018年期间聚焦于人体研究的标准。
关于血糖情况，在2型糖尿病患者中，空腹血糖从12.9降至52.2mg/dL，糖化血红蛋白从0.27降至0.83%，而少数研究中血清胰岛素有所下降。研究论文的持续时间为6至17周。相比降血糖潜力，降血脂潜力的争议更大。此外，据称服用肉桂可减少脂肪量并提高血清抗氧化剂水平，但这些研究方法不准确。研究最多的两种肉桂是桂皮/肉桂和锡兰肉桂/斯里兰卡肉桂。
约1 - 6克这些主要为粉末状的肉桂品种似乎可作为2型糖尿病和其他血糖受损情况的辅助药物治疗。然而，还需要更多对照临床试验。
