Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
Asian J Psychiatr. 2012 Sep;5(3):220-4. doi: 10.1016/j.ajp.2011.11.008. Epub 2012 Mar 6.
The relationship between substance use and psychotic disorder has been complex. Alcohol, cannabis, amphetamines, hallucinogens, and phencyclidine have been implicated as a causative factor for psychotic disorders. It is important to differentiate substance induced psychotic disorders (SIPDs) from primary psychotic disorders as management of the two conditions is different. There is paucity of research in the area of SIPD particularly from Asia. The present study was a retrospective study and it determines retrospectively the incidence rate and clinical characteristics of the SIPDs over a period of 13 years. The incidence of SIPDs was found to be 1.4% and all the subjects were males. In the present study, only alcohol and cannabis were implicated as causative agents for SIPDs. The most common type of psychosis was schizophrenia like psychosis, being more common in the cannabis group. The other forms of psychosis included delusional type, hallucinatory type and affective psychosis. 20% of the subjects had a change in diagnosis to either schizophrenia or affective psychosis on follow-up. The present study showed that the presentation of SIPDs is similar to the primary psychotic disorder and this has management implication.
物质使用与精神病障碍之间的关系一直很复杂。酒精、大麻、苯丙胺、致幻剂和苯环己哌啶已被认为是精神病障碍的致病因素。区分物质引起的精神病障碍（SIPD）与原发性精神病障碍很重要，因为这两种疾病的治疗方法不同。SIPD 领域的研究很少，特别是来自亚洲的研究。本研究是一项回顾性研究，回顾性地确定了 13 年来 SIPD 的发病率和临床特征。SIPD 的发病率为 1.4%，所有受试者均为男性。在本研究中，只有酒精和大麻被认为是 SIPD 的致病因素。最常见的精神病类型是类似精神分裂症的精神病，在大麻组中更为常见。其他形式的精神病包括妄想型、幻觉型和情感性精神病。20%的患者在随访中改变诊断为精神分裂症或情感性精神病。本研究表明，SIPD 的表现与原发性精神病障碍相似，这具有管理意义。
