Reaven G M, Thompson L W, Nahum D, Haskins E
Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
Diabetes Care. 1990 Jan;13(1):16-21. doi: 10.2337/diacare.13.1.16.
The nature and extent of cognitive impairment was examined in 29 healthy elderly subjects (mean age 69.8 yr) with non-insulin-dependent diabetes mellitus (NIDDM) and 30 demographically similar nondiabetic community volunteers (mean age 68 yr). Measures of verbal learning, abstract reasoning, and complex psychomotor functioning were performed more poorly by diabetic than nondiabetic subjects. Conversely, there were no between-group differences in performance on tasks involving pure motor speed and simple verbal abilities. Within the diabetic group, individuals with poorer metabolic control performed more poorly on tasks involving learning, reasoning, and complex psychomotor performance, although this relationship was not evident for simple verbal or motor tasks. These data indicate that older people with NIDDM who are functioning well and perceive themselves as in good health are likely to manifest greater deficits than healthy elderly people in processing complex verbal or nonverbal material. Possible explanatory mechanisms are discussed, and directions for future research are explored.
对29名患有非胰岛素依赖型糖尿病（NIDDM）的健康老年受试者（平均年龄69.8岁）和30名人口统计学特征相似的非糖尿病社区志愿者（平均年龄68岁）的认知障碍的性质和程度进行了研究。与非糖尿病受试者相比，糖尿病患者在言语学习、抽象推理和复杂心理运动功能方面的测试表现更差。相反，在涉及纯运动速度和简单语言能力的任务中，两组之间的表现没有差异。在糖尿病组中，代谢控制较差的个体在涉及学习、推理和复杂心理运动表现的任务中表现更差，尽管这种关系在简单语言或运动任务中并不明显。这些数据表明，功能良好且自我感觉健康的NIDDM老年患者在处理复杂语言或非语言材料时，可能比健康老年人表现出更大的缺陷。文中讨论了可能的解释机制，并探索了未来研究的方向。
