Lindeman R D, Romero L J, LaRue A, Yau C L, Schade D S, Koehler K M, Baumgartner R N, Garry P J
Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-5666, USA.
Diabetes Care. 2001 Sep;24(9):1567-72. doi: 10.2337/diacare.24.9.1567.
To determine whether elderly individuals with type 2 diabetes or impaired glucose tolerance are at increased risk for cognitive impairment compared with individuals with normal glucose tolerance.
Elderly Hispanic individuals (n = 414) and non-Hispanic white individuals (n = 469) aged > or =65 years, randomly selected from the Medicare rolls of Bernalillo County (Albuquerque), NM, were recruited for an interview/examination that included an evaluation of glucose tolerance. Information on nine tests of cognitive function and two measures of depression allowed comparisons between diabetic status and these functions. Comparisons also were made between glycosolated hemoglobin concentrations and these cognitive tests in the 188 participants with diabetes.
None of the mean scores on the tests of cognitive function was significantly lower in the participants with diabetes compared with those participants with normal glucose tolerance after adjustments for ethnicity, sex, age, level of education, and presence of depression, with or without elimination of those with dementia (Mini-Mental State Exam <18). Interestingly, participants with impaired glucose tolerance tended to score higher than those with normal glucose tolerance. No significant associations were found between glycosolated hemoglobin concentrations and cognitive test scores in participants with diabetes.
We could not show any increased risk for cognitive impairment in participants with diabetes compared with those with normal glucose tolerance after adjustments for ethnicity, sex, age, education, and presence of depression, before or after elimination of dementia in this random sample from a biethnic population of predominantly community-dwelling elders.
确定与糖耐量正常的个体相比，2型糖尿病或糖耐量受损的老年人认知障碍风险是否增加。
从新墨西哥州阿尔伯克基市贝纳利洛县医疗保险名单中随机选取年龄≥65岁的西班牙裔老年人（n = 414）和非西班牙裔白人老年人（n = 469），招募他们进行包括糖耐量评估的访谈/检查。关于九项认知功能测试和两项抑郁测量的信息使得能够对糖尿病状态与这些功能进行比较。在188名糖尿病参与者中，还对糖化血红蛋白浓度与这些认知测试进行了比较。
在对种族、性别、年龄、教育水平和抑郁状态进行调整后，无论是否排除患有痴呆症（简易精神状态检查<18）的参与者，糖尿病参与者的认知功能测试平均得分均未显著低于糖耐量正常的参与者。有趣的是，糖耐量受损的参与者得分往往高于糖耐量正常的参与者。在糖尿病参与者中，未发现糖化血红蛋白浓度与认知测试得分之间存在显著关联。
在这个以社区居住的老年人为主的双种族人群随机样本中，在对种族、性别、年龄、教育和抑郁状态进行调整后，无论在排除痴呆症之前还是之后，我们都未发现糖尿病参与者与糖耐量正常的参与者相比认知障碍风险有任何增加。
