LRRK2基因的G2385R和R1628P突变增加了中国大陆南部汉族人群患帕金森病的风险。 - Suppr

LRRK2 G2385R and LRRK2 R1628P increase risk of Parkinson's disease in a Han Chinese population from Southern Mainland China.

作者信息

Fu Xiaoli, Zheng Yifan, Hong Hua, He Yuemei, Zhou Shencun, Guo Caifeng, Liu Yanmei, Xian Wenbiao, Zeng Jinsheng, Li Jinru, Liu Zhuolin, Chen Ling, Pei Zhong

出版信息

Parkinsonism Relat Disord. 2013 Mar;19(3):397-8. doi: 10.1016/j.parkreldis.2012.08.007. Epub 2012 Sep 13.

DOI:10.1016/j.parkreldis.2012.08.007

PMID:22981185

Abstract

摘要

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LRRK2 G2385R and LRRK2 R1628P increase risk of Parkinson's disease in a Han Chinese population from Southern Mainland China.LRRK2基因的G2385R和R1628P突变增加了中国大陆南部汉族人群患帕金森病的风险。

Parkinsonism Relat Disord. 2013 Mar;19(3):397-8. doi: 10.1016/j.parkreldis.2012.08.007. Epub 2012 Sep 13.

An association analysis of the R1628P and G2385R polymorphisms of the LRRK2 gene in multiple system atrophy in a Chinese population.中国人群中LRRK2基因R1628P和G2385R多态性与多系统萎缩的关联分析

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LRRK2 R1628P contributes to Parkinson's disease susceptibility in Chinese Han populations from mainland China.LRRK2基因的R1628P突变对中国大陆汉族人群帕金森病易感性有影响。

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MAPT IVS1+124 C>G modifies risk of LRRK2 G2385R for Parkinson's disease in Chinese individuals.在中国人群中，微管相关蛋白tau基因内含子1+124 C>G修饰了富含亮氨酸重复激酶2基因G2385R导致帕金森病的风险。

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LRRK2 G2385R and LRRK2 R1628P increase risk of Parkinson's disease in a Han Chinese population from Southern Mainland China.

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