电压门控钙离子通道β亚基的结构与功能
Structure and function of the β subunit of voltage-gated Ca²⁺ channels.
作者信息
Buraei Zafir, Yang Jian
机构信息
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
出版信息
Biochim Biophys Acta. 2013 Jul;1828(7):1530-40. doi: 10.1016/j.bbamem.2012.08.028. Epub 2012 Sep 7.
Abstract
The voltage-gated Ca²⁺ channel β subunit (Ca(v)β) is a cytosolic auxiliary subunit that plays an essential role in regulating the surface expression and gating properties of high-voltage activated (HVA) Ca²⁺ channels. It is also crucial for the modulation of HVA Ca²⁺ channels by G proteins, kinases, Ras-related RGK GTPases, and other proteins. There are indications that Ca(v)β may carry out Ca²⁺ channel-independent functions. Ca(v)β knockouts are either non-viable or result in a severe pathophysiology, and mutations in Ca(v)β have been implicated in disease. In this article, we review the structure and various biological functions of Ca(v)β, as well as recent advances. This article is part of a Special Issue entitled: Calcium channels.
摘要
电压门控性Ca²⁺通道β亚基（Ca(v)β）是一种胞质辅助亚基，在调节高电压激活（HVA）Ca²⁺通道的表面表达和门控特性中发挥着至关重要的作用。它对于G蛋白、激酶、Ras相关的RGK GTP酶及其他蛋白质对HVA Ca²⁺通道的调节也至关重要。有迹象表明Ca(v)β可能执行不依赖于Ca²⁺通道的功能。Ca(v)β基因敲除小鼠要么无法存活，要么导致严重的病理生理学改变，并且Ca(v)β中的突变与疾病有关。在本文中，我们综述了Ca(v)β的结构、各种生物学功能以及近期进展。本文是名为“钙通道”的特刊的一部分。
相似文献
1
Structure and function of the β subunit of voltage-gated Ca²⁺ channels.
Biochim Biophys Acta. 2013 Jul;1828(7):1530-40. doi: 10.1016/j.bbamem.2012.08.028. Epub 2012 Sep 7.
2
The ß subunit of voltage-gated Ca2+ channels.
Physiol Rev. 2010 Oct;90(4):1461-506. doi: 10.1152/physrev.00057.2009.
3
Voltage-dependent calcium channels.
Gen Physiol Biophys. 2005 Jun;24 Suppl 1:1-78.
4
A CaVbeta SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ channels.
J Gen Physiol. 2005 Oct;126(4):365-77. doi: 10.1085/jgp.200509354.
5
Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes.
Channels (Austin). 2010 Jan-Feb;4(1):42-50. doi: 10.4161/chan.4.1.10562. Epub 2010 Jan 9.
6
Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.
PLoS One. 2008;3(10):e3560. doi: 10.1371/journal.pone.0003560. Epub 2008 Oct 29.
7
Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions.
J Biol Chem. 2005 Apr 1;280(13):12474-85. doi: 10.1074/jbc.M412140200. Epub 2005 Jan 25.
8
Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.
PLoS One. 2012;7(5):e37079. doi: 10.1371/journal.pone.0037079. Epub 2012 May 10.
9
Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation.
Biophys J. 2004 Aug;87(2):844-57. doi: 10.1529/biophysj.104.041152.
10
A novel molecular inactivation determinant of voltage-gated CaV1.2 L-type Ca2+ channel.
Neuroscience. 2006;139(4):1275-87. doi: 10.1016/j.neuroscience.2006.01.028. Epub 2006 Mar 14.
引用本文的文献
1
Novel Drug Targets in Diastolic Heart Disease.
Int J Mol Sci. 2025 Aug 20;26(16):8055. doi: 10.3390/ijms26168055.
2
Identification of CaVβ1 Isoforms Required for Neuromuscular Junction Formation and Maintenance.
Cells. 2025 Aug 6;14(15):1210. doi: 10.3390/cells14151210.
3
Spatially-distinct programming of macrophage diversity within the granulomas of infected nonhuman primates.
bioRxiv. 2025 Jun 17:2025.06.12.659348. doi: 10.1101/2025.06.12.659348.
4
Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases.
Cell Commun Signal. 2025 Jul 14;23(1):337. doi: 10.1186/s12964-025-02347-0.
5
Voltage-Gated Ion Channels in Neuropathic Pain Signaling.
Life (Basel). 2025 May 30;15(6):888. doi: 10.3390/life15060888.
6
Mapping the interaction surface between Caβ and actin and its role in calcium channel clearance.
Nat Commun. 2025 May 10;16(1):4352. doi: 10.1038/s41467-025-59548-x.
7
Upregulation of astrocytic mitochondrial functions via Korean red ginseng-induced CREB-BK-HIF-1 axis through L-type Ca channel subunits 1C and 4.
J Cereb Blood Flow Metab. 2025 May 2:271678X251332760. doi: 10.1177/0271678X251332760.
8
The membrane-associated β2e-subunit of voltage-gated calcium channels translocates to the nucleus and regulates gene expression.
Front Physiol. 2025 Apr 14;16:1555934. doi: 10.3389/fphys.2025.1555934. eCollection 2025.
9
Exploring the potential for gene therapy in Cav1.4-related retinal channelopathies.
Channels (Austin). 2025 Dec;19(1):2480089. doi: 10.1080/19336950.2025.2480089. Epub 2025 Mar 25.
10
Inactivation of CaV1 and CaV2 channels.
J Gen Physiol. 2025 Mar 3;157(2). doi: 10.1085/jgp.202313531. Epub 2025 Jan 30.
本文引用的文献
1
The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.
J Neurosci. 2012 May 30;32(22):7602-13. doi: 10.1523/JNEUROSCI.5727-11.2012.
2
Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels.
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3161-6. doi: 10.1073/pnas.1121434109. Epub 2012 Feb 2.
3
Trafficking and stability of voltage-gated calcium channels.
Cell Mol Life Sci. 2012 Mar;69(6):843-56. doi: 10.1007/s00018-011-0843-y. Epub 2011 Oct 2.
4
Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels.
J Physiol. 2011 Sep 15;589(Pt 18):4437-55. doi: 10.1113/jphysiol.2011.214247. Epub 2011 Jul 11.
5
Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy.
Cell. 2011 Jun 24;145(7):1036-48. doi: 10.1016/j.cell.2011.05.025.
6
Homodimerization of the Src homology 3 domain of the calcium channel β-subunit drives dynamin-dependent endocytosis.
J Biol Chem. 2011 Jun 24;286(25):22203-10. doi: 10.1074/jbc.M110.201871. Epub 2011 Apr 18.
7
Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene.
J Biol Chem. 2011 May 6;286(18):15875-82. doi: 10.1074/jbc.M111.227819. Epub 2011 Feb 28.
8
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.
J Biol Chem. 2011 Mar 18;286(11):9598-611. doi: 10.1074/jbc.M110.195909. Epub 2011 Jan 13.
9
Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels.
J Biol Chem. 2011 Mar 18;286(11):8829-38. doi: 10.1074/jbc.M110.166520. Epub 2011 Jan 10.
10
The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motif.
J Biol Chem. 2011 Mar 18;286(11):9677-87. doi: 10.1074/jbc.M110.187864. Epub 2011 Jan 10.
Zotero 插件