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电压门控钙离子通道β亚基的结构与功能

Structure and function of the β subunit of voltage-gated Ca²⁺ channels.

作者信息

Buraei Zafir, Yang Jian

机构信息

Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

出版信息

Biochim Biophys Acta. 2013 Jul;1828(7):1530-40. doi: 10.1016/j.bbamem.2012.08.028. Epub 2012 Sep 7.

DOI:10.1016/j.bbamem.2012.08.028
PMID:22981275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3587009/
Abstract

The voltage-gated Ca²⁺ channel β subunit (Ca(v)β) is a cytosolic auxiliary subunit that plays an essential role in regulating the surface expression and gating properties of high-voltage activated (HVA) Ca²⁺ channels. It is also crucial for the modulation of HVA Ca²⁺ channels by G proteins, kinases, Ras-related RGK GTPases, and other proteins. There are indications that Ca(v)β may carry out Ca²⁺ channel-independent functions. Ca(v)β knockouts are either non-viable or result in a severe pathophysiology, and mutations in Ca(v)β have been implicated in disease. In this article, we review the structure and various biological functions of Ca(v)β, as well as recent advances. This article is part of a Special Issue entitled: Calcium channels.

摘要

电压门控性Ca²⁺通道β亚基（Ca(v)β）是一种胞质辅助亚基，在调节高电压激活（HVA）Ca²⁺通道的表面表达和门控特性中发挥着至关重要的作用。它对于G蛋白、激酶、Ras相关的RGK GTP酶及其他蛋白质对HVA Ca²⁺通道的调节也至关重要。有迹象表明Ca(v)β可能执行不依赖于Ca²⁺通道的功能。Ca(v)β基因敲除小鼠要么无法存活，要么导致严重的病理生理学改变，并且Ca(v)β中的突变与疾病有关。在本文中，我们综述了Ca(v)β的结构、各种生物学功能以及近期进展。本文是名为“钙通道”的特刊的一部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f4/3587009/8442935277a2/nihms-409147-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f4/3587009/0b90239fdc45/nihms-409147-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f4/3587009/59f6f04594a5/nihms-409147-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f4/3587009/8442935277a2/nihms-409147-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f4/3587009/0b90239fdc45/nihms-409147-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f4/3587009/59f6f04594a5/nihms-409147-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45f4/3587009/8442935277a2/nihms-409147-f0003.jpg

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J Neurosci. 2012 May 30;32(22):7602-13. doi: 10.1523/JNEUROSCI.5727-11.2012.
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Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels.膜定位的β亚基改变了 PIP2 对高电压激活 Ca2+通道的调节。
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3161-6. doi: 10.1073/pnas.1121434109. Epub 2012 Feb 2.
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Trafficking and stability of voltage-gated calcium channels.
bioRxiv. 2025 Jun 17:2025.06.12.659348. doi: 10.1101/2025.06.12.659348.
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Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases.电压门控钙通道的降解：神经和心血管疾病中的机制与应用
Cell Commun Signal. 2025 Jul 14;23(1):337. doi: 10.1186/s12964-025-02347-0.
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Voltage-Gated Ion Channels in Neuropathic Pain Signaling.神经病理性疼痛信号传导中的电压门控离子通道
Life (Basel). 2025 May 30;15(6):888. doi: 10.3390/life15060888.
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Mapping the interaction surface between Caβ and actin and its role in calcium channel clearance.绘制Caβ与肌动蛋白之间的相互作用表面及其在钙通道清除中的作用。
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J Cereb Blood Flow Metab. 2025 May 2:271678X251332760. doi: 10.1177/0271678X251332760.
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