Donnet A
Pole neurosciences cliniques, hôpital Timone, 264, rue St-Pierre, 13005 Marseille, France.
Rev Neurol (Paris). 2012 Oct;168(10):685-90. doi: 10.1016/j.neurol.2012.07.014. Epub 2012 Sep 13.
The pathogenesis and treatment paradigm for idiopathic intracranial hypertension (IIH) are controversial. Transverse sinus stenosis is seen in the majority of patients with IIH and appears to play a role in the disease process. The debate continues as to whether transverse sinus stenosis is a primary or secondary process relative to raised intracranial pressure. While the role of transverse sinus stenosis in IIH pathogenesis remains controversial, modeling studies suggest that stent placement within a transverse sinus stenosis with a significant pressure gradient should decrease cerebral venous pressure, improve CSF resorption in the venous system, and thereby reduce intracranial (CSF) pressure, improving the symptoms of IIH and reducing papilledema. Beside the classical surgical treatments, venous sinus stenting could be a treatment option for many patients with IIH. However, additional work, preferably controlled prospective studies, needs to be performed to prove its safety and efficacy. The goal of this article is to review the current literature on dural venous sinus stenting.
特发性颅内高压（IIH）的发病机制和治疗模式存在争议。横窦狭窄在大多数IIH患者中可见，且似乎在疾病过程中起作用。关于横窦狭窄相对于颅内压升高是原发性还是继发性过程的争论仍在继续。虽然横窦狭窄在IIH发病机制中的作用仍存在争议，但模型研究表明，在存在显著压力梯度的横窦狭窄处放置支架应可降低脑静脉压，改善静脉系统中的脑脊液吸收，从而降低颅内（脑脊液）压力，改善IIH症状并减轻视乳头水肿。除了传统的手术治疗外，静脉窦支架置入术可能是许多IIH患者的一种治疗选择。然而，需要进行更多的工作，最好是对照前瞻性研究，以证明其安全性和有效性。本文的目的是综述目前关于硬脑膜静脉窦支架置入术的文献。
