Delen Firuze, Peker Elif, Onay Mehmet, Altay Çetin Murat, Tekeli Oya, Togay Işıkay Canan
Department of Neurology, Ankara University Faculty of Medicine, Ankara, Turkey.
Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey.
Neuroophthalmology. 2018 Jul 19;43(2):81-90. doi: 10.1080/01658107.2018.1493514. eCollection 2019 Apr.
The objective of our study was to provide a comparative assessment of previously reported magnetic resonance imaging (MRI) parameters in primary and secondary pseudotumor cerebri (PTC) patients, to examine their diagnostic contribution, and to evaluate their association with symptoms, neuro-ophthalmological findings, laboratory results, and cerebrospinal fluid characteristics. Twenty-eight consecutive patients with PTC were included in the study. Age- and sex-matched 20 individuals with normal neurologic examination served as the control group. Modified Dandy Criteria were used for the diagnosis of PTC. Orbital and cranial MRI and MR venography of all patients and controls were assessed by three radiologists. According to our study, posterior flattening of the globe (64% sensitive, 100% specific), optic nerve sheath distention (46% sensitive, 100% specific), vertical tortuosity of the optic nerve (30% sensitive, 95% specific), and partial empty sella (43% sensitive, 100% specific) emerged as particularly valuable markers for a diagnosis of PTC.
我们研究的目的是对先前报道的原发性和继发性假性脑瘤（PTC）患者的磁共振成像（MRI）参数进行比较评估，以检验其诊断价值，并评估它们与症状、神经眼科检查结果、实验室检查结果及脑脊液特征之间的关联。本研究纳入了28例连续的PTC患者。20例年龄和性别匹配且神经系统检查正常的个体作为对照组。采用改良的丹迪标准诊断PTC。三位放射科医生对所有患者及对照组进行眼眶和头颅MRI及磁共振静脉血管造影评估。根据我们的研究，眼球后部扁平（敏感性64%，特异性100%）、视神经鞘扩张（敏感性46%，特异性100%）、视神经垂直迂曲（敏感性30%，特异性95%）及部分空蝶鞍（敏感性43%，特异性100%）是诊断PTC特别有价值的指标。
