Medicine and Health Sciences Faculty, Universitat Internacional de Catalunya, Barcelona, Spain.
Parkinsonism Relat Disord. 2013 Jan;19(1):115-9. doi: 10.1016/j.parkreldis.2012.08.008. Epub 2012 Sep 13.
Independent validation of the Non motor Symptoms Scale in Parkinson's disease (NMSS) based on a cross-culturally adapted Brazilian version.
Parkinson's disease (PD) patients were evaluated by means of the Scales for Outcomes in Parkinson's disease-Motor (SCOPA-M), Autonomic, Cognition, and Psychosis; Hoehn and Yahr staging (H&Y); Berg Balance Scale; PD Sleep Scale; Clinical Impression of Severity Index for PD (CISI-PD); PDQ-39; and EQ-5D. The following clinimetric attributes were explored for the NMSS: acceptability, scaling assumptions, reliability, construct validity, and precision.
150 patients were assessed (mean age 63.1 years; 56.7% males; mean duration of illness 8.7 years; HY median: 2). Mean NMSS was 48.9 (SD 36.3; median 42; skewness 1.3). Neither floor nor ceiling effect was observed on the NMSS total score. For domains, the Cronbach's alpha coefficient ranged from 0.40 to 0.82. The NMSS total score correlated significantly with SCOPA-AUT (r(S) = 0.65) and with those scales measuring related constructs (r(S) = 0.46-0.57). NMSS significantly increased as the H&Y stage increased (Kruskal-Wallis, p < 0.0001). These values were quite close to those from the original validation studies.
The NMSS is a reliable and valid measure to evaluate non motor symptoms in Brazilian PD patients.
基于跨文化适应的巴西版本，对帕金森病（PD）患者的非运动症状量表（NMSS）进行独立验证。
通过帕金森病评定量表-运动（SCOPA-M）、自主神经、认知和精神病学、Hoehn 和 Yahr 分期（H&Y）、Berg 平衡量表、帕金森病睡眠量表、帕金森病临床严重程度指数临床印象（CISI-PD）、帕金森病生活质量问卷 39 项（PDQ-39）和 EQ-5D 对 PD 患者进行评估。探讨 NMSS 的以下临床属性：可接受性、刻度假设、可靠性、结构有效性和精密度。
评估了 150 例患者（平均年龄 63.1 岁；56.7%为男性；平均病程 8.7 年；H&Y 中位数：2）。NMSS 平均值为 48.9（SD 36.3；中位数 42；偏度 1.3）。NMSS 总分无地板或天花板效应。在各领域，Cronbach's alpha 系数范围为 0.40 至 0.82。NMSS 总分与 SCOPA-AUT 显著相关（r（S）=0.65），与那些测量相关结构的量表也显著相关（r（S）=0.46-0.57）。NMSS 随着 H&Y 分期的增加而显著增加（Kruskal-Wallis，p<0.0001）。这些值与原始验证研究非常接近。
NMSS 是一种可靠有效的评估巴西 PD 患者非运动症状的工具。
