Department of Neurology, The Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia DF, Brazil.
Mov Disord. 2010 Jan 30;25(2):205-12. doi: 10.1002/mds.22882.
Cross-cultural adaptation and psychometric assessment of the Scales for Outcomes in Parkinson's Disease-Autonomic questionnaire (SCOPA-AUT) Brazilian Portuguese version. 150 consecutive Parkinson's disease (PD) patients were evaluated by means of the SCOPA-motor scale (SCOPA-M), SCOPA-cognition (SCOPA-COG), Hoehn and Yahr staging (H&Y), nonmotor symptoms scale (NMSS), PD questionnaire (PDQ-39), and SCOPA-AUT. The following psychometric attributes were explored: acceptability, scaling assumptions, reliability, precision, and construct validity. Patients' age (mean +/- standard deviation) was 63.1 +/- 11.1 years (56.7% men; duration of disease, 8.7 +/- 5.3 years; median H&Y, 2). Mean SCOPA-AUT was 23.0 +/- 11.2. SCOPA-AUT did not show floor or ceiling effect. As a whole, the SCOPA-AUT item-domain correlation was satisfactory, except for items 2 (Saliva), 7 (Faecal incontinence), 16 (Syncope), and 19 (Cold intolerance) (|r(S)| = 0.03-0.32). Internal consistency was adequate, except for thermoregulatory and cardiovascular domains (alpha coefficients, 0.56 and 0.63, respectively). Intraclass correlation coefficient for the total score was 0.71, whereas weighted kappa for individual items ranged from 0.15 to 0.71 (only items 4 and 7 were <0.40). Standard error of measurement was 6.04. The SCOPA-AUT total score correlated closely with the NMSS total score (r(S) = 0.65) and PDQ-39 Summary Index (r(S) = 0.61) and at a moderate level with H&Y staging (r(S) = 0.35) and SCOPA-MS total score (r(S) = 0.39) (all r(S) values, P < 0.0001). Correlation of SCOPA-AUT with SCOPA-COG was weak. SCOPA-AUT significantly increased as the H&Y stage increased (Kruskal-Wallis, P < 0.0001). The SCOPA-AUT Brazilian Portuguese version is an acceptable, reliable, and valid questionnaire to evaluate autonomic dysfunction in PD.
帕金森病自主神经问卷（SCOPA-AUT）巴西葡萄牙语版本的跨文化适应性和心理测量评估。对 150 例连续的帕金森病（PD）患者进行了评估，使用 SCOPA-运动量表（SCOPA-M）、SCOPA-认知量表（SCOPA-COG）、Hoehn 和 Yahr 分期（H&Y）、非运动症状量表（NMSS）、PD 问卷（PDQ-39）和 SCOPA-AUT。探讨了以下心理测量属性：可接受性、定标假设、可靠性、精密度和结构有效性。患者的年龄（平均值±标准差）为 63.1±11.1 岁（56.7%为男性；疾病持续时间为 8.7±5.3 年；中位数 H&Y 为 2）。平均 SCOPA-AUT 为 23.0±11.2。SCOPA-AUT 未显示地板或天花板效应。总体而言，SCOPA-AUT 项目-域相关性令人满意，除了项目 2（唾液）、7（大便失禁）、16（晕厥）和 19（对寒冷不耐受）（|r(S)|=0.03-0.32）。内部一致性足够，除了体温调节和心血管领域（alpha 系数分别为 0.56 和 0.63）。总得分的组内相关系数为 0.71，而个体项目的加权 kappa 范围为 0.15 至 0.71（仅项目 4 和 7 ＜0.40）。测量误差的标准误差为 6.04。SCOPA-AUT 总分与 NMSS 总分（r(S)=0.65）和 PDQ-39 综合指数（r(S)=0.61）密切相关，与 H&Y 分期（r(S)=0.35）和 SCOPA-MS 总分（r(S)=0.39）中度相关（所有 r(S)值，P＜0.0001）。SCOPA-AUT 与 SCOPA-COG 的相关性较弱。SCOPA-AUT 随着 H&Y 分期的增加而显著增加（Kruskal-Wallis，P＜0.0001）。SCOPA-AUT 巴西葡萄牙语版本是一种可接受、可靠且有效的问卷，可用于评估 PD 自主神经功能障碍。
