Sardar Zomer, Liaquat Sumayyah, Yousaf Qudsum, Bano Safia, Numan Ahsan
Department of Neurology, District Hospital Nankana Sahib, Lahore, Pakistan.
Department of Neurology, Hussain Lakhani Hospital, Karachi, Pakistan.
Ann Indian Acad Neurol. 2023 Jan-Feb;26(1):39-43. doi: 10.4103/aian.aian_483_22. Epub 2022 Dec 22.
Non-motor symptoms (NMSs) in Parkinson's disease (PD) are often overlooked and thus can impede clinical management and significantly reduce the patient's quality of life.
The study aimed to determine the burden of NMS in the early stages of PD.
A 1-year observational cross-sectional study was conducted at Mayo Hospital, Lahore, in 2019. The MDS-PD criteria were used to diagnose PD patients. The study included patients with Hoehn and Yahr (HY) stages 1-3. The frequency of NMSs was assessed using a non-motor symptom questionnaire (NMSQ), and the non-motor symptom scale (NMSS) score was derived using the NMSS.
A total of 100 PD patients were enrolled in the study. Sixty-three (63%) were males and 37 (37%) were females. Their age ranged between 45 and 75 years with a mean ± SD of 57.46 ± 8.46. At least one NMS was reported by 84% of patients, with neuropsychiatric symptoms (68%) preponderant, followed by a change in taste and smell (64%). The mean NMSS score is 46.22 ± 22.098 (median 44) with a range from 0 to 88, with the trend being increasing score with the advancing stage.
The use of the NMSQ and NMSS tools should be standard in clinical practice to identify the severity of the disease and commence appropriate care.
帕金森病（PD）的非运动症状（NMSs）常常被忽视，因此可能会妨碍临床管理并显著降低患者的生活质量。
本研究旨在确定PD早期阶段非运动症状的负担。
2019年在拉合尔梅奥医院进行了一项为期1年的观察性横断面研究。采用MDS-PD标准诊断PD患者。该研究纳入了Hoehn和Yahr（HY）分期为1-3期的患者。使用非运动症状问卷（NMSQ）评估非运动症状的频率，并使用非运动症状量表（NMSS）得出非运动症状量表评分。
本研究共纳入100例PD患者。其中63例（63%）为男性，37例（37%）为女性。他们的年龄在45至75岁之间，平均±标准差为57.46±8.46。84%的患者报告至少有一种非运动症状，其中神经精神症状占主导（68%），其次是味觉和嗅觉改变（64%）。非运动症状量表平均评分为46.22±22.098（中位数44），范围为0至88，且随着病情进展评分呈上升趋势。
在临床实践中应规范使用NMSQ和NMSS工具来确定疾病的严重程度并开始适当的治疗。
