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[一名免疫功能正常的16个月大女童水痘期间的暴发性肺炎]

[Fulminant pneumonia during varicella in an immunocompetent 16-month-old girl].

作者信息

Asse K-V, Rekik H, Ropert J-C, Pejoan H, Kharsa G

机构信息

Service de pédiatrie-néonatologie, centre hospitalier Courbevoie-Neuilly-Puteaux, 36, boulevard du Général-Leclerc, BP 79, 92205 Neuilly-sur-Seine cedex, France.

出版信息

Arch Pediatr. 2012 Oct;19(10):1074-8. doi: 10.1016/j.arcped.2012.07.006. Epub 2012 Sep 13.

Abstract

Varicella is a cosmopolitan communicable disease caused by varicella-zoster virus (VZV) characterized by papulovesicular rash and fever. Management of fever and pruritus and prevention of bacterial infection are the main aspects of treatment. Severe complications and death may occur in pregnancy, in newborns, in adults, and in immunocompromised children. Contrary to immunocompetent adults in whom pneumonia occurs in 50% of cases during varicella, this complication in children is rare. We report a fatal case of pneumonia with severe hypoxemia during varicella in an immunocompetent 16-month-old child. Based on a literature review, we discuss the main aspects of diagnosis, treatment, and prognosis of varicella. Active immunization of children after 12 months of age is the primary prevention of varicella.

摘要

水痘是一种由水痘-带状疱疹病毒(VZV)引起的全球性传染病,其特征为丘疹水疱性皮疹和发热。治疗的主要方面是控制发热和瘙痒以及预防细菌感染。妊娠期间、新生儿期、成人以及免疫功能低下的儿童可能会出现严重并发症甚至死亡。与免疫功能正常的成年人在水痘期间50%会发生肺炎不同,这种并发症在儿童中很少见。我们报告了一例16个月大免疫功能正常的儿童在水痘期间发生伴有严重低氧血症的致命性肺炎病例。基于文献综述,我们讨论了水痘的诊断、治疗和预后的主要方面。12个月龄后的儿童主动免疫是预防水痘的主要措施。

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