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从藤黄科植物汉氏省藤树脂中分离得到的细胞毒烷氧基呫吨酮。

Cytotoxic alkoxylated xanthones from the resin of Garcinia hanburyi.

机构信息

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.

出版信息

Fitoterapia. 2012 Dec;83(8):1548-52. doi: 10.1016/j.fitote.2012.08.023. Epub 2012 Sep 6.

DOI:10.1016/j.fitote.2012.08.023
PMID:22981505
Abstract

Three new xanthones, garcinolic acid (1), 10α-ethoxy-9,10-dihydromorellic acid (2), and 10α-ethoxy-9,10-dihydrogambogenic acid (3), along with six known compounds were isolated from the resin of Garcinia hanburyi. These compounds were tested for their cytotoxicities against A549, HCT116, SK-BR-3 and HepG2, and showed high inhibitory effects on the cell lines.

摘要

从藤黄科植物藤黄树脂中分离得到三个新的紫檀烷酮化合物,即 Garcinolic 酸(1)、10α-乙氧基-9,10-二氢莫雷酸(2)和 10α-乙氧基-9,10-二氢甘珀酸(3),以及六个已知化合物。对这些化合物进行了体外细胞毒活性测试,结果表明它们对 A549、HCT116、SK-BR-3 和 HepG2 细胞株具有较强的抑制作用。

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