Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Psychoneuroendocrinology. 2013 May;38(5):638-47. doi: 10.1016/j.psyneuen.2012.08.006. Epub 2012 Sep 14.
Low-grade systemic inflammation may contribute to the development of depression. We tested the hypothesis that elevated plasma levels of the inflammatory marker fibrinogen are associated with psychological distress, use of antidepressant medication, and with hospitalization with depression in the general population.
We examined 73,367 20-100 year old men and women from two large population-based studies, the Copenhagen General Population Study and the Copenhagen City Heart Study. We measured plasma fibrinogen and recorded symptoms of psychological distress, use of antidepressant medication, and hospitalization with depression in both cross-sectional and prospective studies.
In cross-sectional analyses, a stepwise increase in fibrinogen percentile categories was associated with a stepwise increase in risk of psychological distress, use of antidepressant medication, and hospitalization with depression (p-trend 2×10(-11) to 5×10(-95)). Furthermore, when different classes of antidepressant medication were examined, a stepwise increase in fibrinogen percentile categories was associated with a stepwise increase in risk of use of Selective Serotonin Reuptake Inhibitors and Tricyclic Antidepressants (p-trend 7×10(-18) and 6×10(-7), respectively). In prospective analyses, stepwise increasing fibrinogen percentile categories also associated with stepwise increasing risk of hospitalization with depression (p-trend=7×10(-6)): age and gender adjusted hazard ratios were 1.13 (95% confidence interval 0.70-1.83) for the 25.1-50th percentiles, 1.53 (0.97-2.42) for the 50.1-75th percentiles, 1.82 (1.11-2.97) for the 75.1-90th percentiles, 2.10 (1.12-3.95) for the 90.1-95th percentiles, and 3.23 (1.79-5.85) for the >95th percentiles, versus the 0-25th percentiles.
Elevated levels of fibrinogen were associated with psychological distress, use of antidepressant medication, and with hospitalization with depression in 73,367 individuals from the general population, in cross-sectional studies and in prospective studies for hospitalization with depression.
低度全身炎症可能导致抑郁的发生。我们检验了这样一个假说，即升高的血浆纤维蛋白原炎症标志物水平与一般人群中的心理困扰、抗抑郁药物的使用以及因抑郁住院相关。
我们检测了来自两项大型人群研究（哥本哈根普通人群研究和哥本哈根城市心脏研究）的 73367 名 20-100 岁的男性和女性的血浆纤维蛋白原水平，并记录了心理困扰、抗抑郁药物使用和因抑郁住院的症状。在横断面和前瞻性研究中，我们对这些数据进行了分析。
在横断面分析中，纤维蛋白原百分位类别呈阶梯式升高与心理困扰、抗抑郁药物使用和因抑郁住院的风险呈阶梯式升高相关（趋势检验 P<2×10(-11)至 5×10(-95)）。此外，当对不同类别的抗抑郁药物进行检查时，纤维蛋白原百分位类别呈阶梯式升高与使用选择性 5-羟色胺再摄取抑制剂和三环类抗抑郁药的风险呈阶梯式升高相关（趋势检验 P<7×10(-18)和 6×10(-7)）。在前瞻性分析中，纤维蛋白原百分位类别也呈阶梯式升高与因抑郁住院的风险呈阶梯式升高相关（趋势检验 P=7×10(-6)）：经年龄和性别校正后的危险比分别为 25.1-50 百分位（95%置信区间为 0.70-1.83）、50.1-75 百分位（0.97-2.42）、75.1-90 百分位（1.11-2.97）、90.1-95 百分位（1.12-3.95）和 >95 百分位（1.79-5.85）与 0-25 百分位相比。
在来自一般人群的 73367 名个体中，在横断面研究和前瞻性研究中，纤维蛋白原水平升高与心理困扰、抗抑郁药物的使用以及因抑郁住院相关。
