Kim Hee Jin, Kim Hye Ri, Jin Jae-Chan, Han Doug Hyun, Kim Sun Mi
Department of Psychiatry, Chung-Ang University College of Medicine, Seoul, Korea.
Department of Social Welfare, Graduate School of Soongsil University, Seoul, Korea.
Clin Psychopharmacol Neurosci. 2021 May 31;19(2):361-366. doi: 10.9758/cpn.2021.19.2.361.
In somatic symptom disorder (SSD), cognitive dysfunction is related to perceptive distortion that excessively amplifies bodily sensations. The association between high body mass index (BMI) and cognitive dysfunction could be attributed to underlying systemic inflammation. We aimed to evaluate whether patients with SSD and high BMI exhibit increased somatic symptom severity and whether this is mediated by cognitive dysfunction.
This retrospective, cross-sectional study was conducted on 54 patients with SSD (20 males/34 females, mean age ± standard deviation: 40.65 ± 13.23 years). Participants' BMI, laboratory data including complete blood count and lipid profile, results from the Korean Wechsler Adult Intelligence Scale-IV, and scores of the Korean-Symptom Checklist 95-Somatization (SCL95-SOM) were analyzed. We performed a path analysis to evaluate BMI as a predictor of somatic symptoms.
In a path analysis, the SCL95-SOM score was directly influenced by working memory (b = -0.326, p = 0.032), which was significantly influenced by BMI (b = -0.338, p = 0.009), although there was no direct effect of BMI on the SCL95-SOM score. The path analytic model showed a close fit to the data with the following values: χ (df) = 0.918 (1), p = 0.338, root mean square error of approximation = 0.000 (< 0.001), and comparative fit index = 1.00.
Patients with SSD and high BMI may exhibit increased somatic symptom severity, and this is mediated by working memory dysfunction. Weight management may help improve symptoms in patients with SSD and high BMI.
在躯体症状障碍（SSD）中，认知功能障碍与感知扭曲有关，感知扭曲会过度放大身体感觉。高体重指数（BMI）与认知功能障碍之间的关联可能归因于潜在的全身炎症。我们旨在评估患有SSD且BMI高的患者是否表现出更高的躯体症状严重程度，以及这是否由认知功能障碍介导。
对54例SSD患者（20例男性/34例女性，平均年龄±标准差：40.65±13.23岁）进行了这项回顾性横断面研究。分析了参与者的BMI、包括全血细胞计数和血脂谱在内的实验室数据、韩国韦氏成人智力量表-IV的结果以及韩国症状清单95-躯体化（SCL95-SOM）的得分。我们进行了路径分析，以评估BMI作为躯体症状的预测指标。
在路径分析中，SCL95-SOM得分直接受工作记忆影响（b = -0.326，p = 0.032），而工作记忆受BMI显著影响（b = -0.338，p = 0.009），尽管BMI对SCL95-SOM得分没有直接影响。路径分析模型与数据拟合良好，具体值如下：χ（自由度）= 0.918（1），p = 0.338，近似均方根误差 = 0.000（<0.001），比较拟合指数 = 1.00。
患有SSD且BMI高的患者可能表现出更高的躯体症状严重程度，这由工作记忆功能障碍介导。体重管理可能有助于改善患有SSD且BMI高的患者的症状。
