Université Paris-Sud, Faculté de Pharmacie, UMR CNRS 8612, Institut Galien Paris-Sud, 5, rue JB Clément, 92296 Châtenay-Malabry Cedex, France.
Drug Discov Today. 2013 Jan;18(1-2):99-104. doi: 10.1016/j.drudis.2012.08.007. Epub 2012 Sep 5.
In the past few years, the growth of nanometric size drug delivery systems (DDS) has burst into challenging innovations enabling real progresses to achieve oral delivery of anticancer drugs. DDS, such as polymeric nanoparticles, micelles, dendrimers and lipid-based formulations enable physico-chemical properties of cytotoxic agents to be improved and oral bioavailability to be enhanced. In this review we highlight current DDS used for the oral delivery of anticancer drugs.
在过去的几年中，纳米尺寸药物传递系统（DDS）的发展如雨后春笋般涌现，为实现抗癌药物的口服递送带来了极具挑战性的创新。DDS，如聚合物纳米粒子、胶束、树枝状大分子和基于脂质的制剂，能够改善细胞毒性药物的物理化学性质并提高口服生物利用度。在本文中，我们重点介绍了目前用于抗癌药物口服递送的 DDS。
