Yu Bin, Li Yanli, Lin Yuxian, Zhu Yuanying, Hao Teng, Wu Yan, Sun Zheng, Yang Xin, Xu Hui
School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Yantai University, Yantai, China.
Department of Pharmacy, Binzhou Hospital of Traditional Chinese Medicine, Binzhou, China.
Front Pharmacol. 2023 Jan 4;13:1071868. doi: 10.3389/fphar.2022.1071868. eCollection 2022.
Silk fibroin has been widely used in biological fields due to its biocompatibility, mechanical properties, biodegradability, and safety. Recently, silk fibroin as a drug carrier was developed rapidly and achieved remarkable progress in cancer treatment. The silk fibroin-based delivery system could effectively kill tumor cells without significant side effects and drug resistance. However, few studies have been reported on silk fibroin delivery systems for antitumor therapy. The advancement of silk fibroin-based drug delivery systems research and its applications in cancer therapy are highlighted in this study. The properties, applications, private opinions, and future prospects of silk fibroin carriers are discussed to understand better the development of anti-cancer drug delivery systems, which may also contribute to advancing silk fibroin innovation.
丝素蛋白因其生物相容性、机械性能、生物降解性和安全性而在生物领域得到广泛应用。近年来，丝素蛋白作为药物载体发展迅速，并在癌症治疗方面取得了显著进展。基于丝素蛋白的递送系统可以有效杀死肿瘤细胞，且无明显副作用和耐药性。然而，关于用于抗肿瘤治疗的丝素蛋白递送系统的研究报道较少。本研究重点介绍了基于丝素蛋白的药物递送系统研究进展及其在癌症治疗中的应用。讨论了丝素蛋白载体的性质、应用、个人观点及未来前景，以便更好地了解抗癌药物递送系统的发展，这也可能有助于推动丝素蛋白的创新。
