Department of Molecular Pathology, Tokyo Medical University, 6-1-1, Shinjyuku, Tokyo, 160-8402, Japan.
Adv Drug Deliv Rev. 2013 Mar;65(3):398-401. doi: 10.1016/j.addr.2012.07.019. Epub 2012 Aug 18.
A variety of cells release membrane vesicles, such as exosomes and microvesicles (MVs), that are thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents throughout the body. There have been considerable efforts to use MVs as diagnostic or prognostic markers because their composition is reflective of minor physiological changes. Furthermore, recent studies demonstrate that MVs derived from infected cells and tumors contribute to disease pathogenesis. This review presents an overview of the potential roles of MVs with respect to clinical diagnosis and disease pathogenesis.
多种细胞会释放膜囊泡，如外泌体和微泡（MV），这些囊泡被认为在细胞间通讯、抗原呈递以及病原体在全身的传播中发挥关键作用。人们已经做出了相当大的努力来使用 MV 作为诊断或预后标志物，因为它们的组成反映了较小的生理变化。此外，最近的研究表明，源自感染细胞和肿瘤的 MV 有助于疾病的发病机制。本综述概述了 MV 在临床诊断和疾病发病机制方面的潜在作用。
