College of Chemistry and Materials Science, Ludong University, Yantai 264025, China.
Int J Biol Macromol. 2012 Dec;51(5):1109-15. doi: 10.1016/j.ijbiomac.2012.08.033. Epub 2012 Sep 7.
In this paper, self-assembled thermo-sensitive polyelectrolyte complex nanoparticles formed from chitosan-graft-poly(N-isopropylacrylamide)/carboxymethyl cellulose (CS-g-PNIPAM/CMC) were prepared for entrapment and release of 5-fluorouracil (5-FU). The morphology and size of the nanoparticles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The polyelectrolyte complex nanoparticles showed a narrow distribution with an average diameter of about 200 nm. The hydrogen bonding interaction between nanoparticles and 5-FU was determined by Fourier-transformed infrared spectroscopy (FTIR). Increasing temperature or pH of the solutions, a sustained and controlled drug release was observed. The chemical cross-linking was an efficient way to decrease the drug release rate at the initial stage. The novel complex nanoparticles with environmentally sensitive properties are expected to be used in the field of intelligent drug delivery system.
本文制备了壳聚糖接枝聚（N-异丙基丙烯酰胺）/羧甲基纤维素（CS-g-PNIPAM/CMC）自组装温敏性聚电解质复合纳米粒子，用于包封和释放 5-氟尿嘧啶（5-FU）。通过透射电子显微镜（TEM）和动态光散射（DLS）观察纳米粒子的形态和尺寸。聚电解质复合纳米粒子的平均直径约为 200nm，呈窄分布。通过傅里叶变换红外光谱（FTIR）确定了纳米粒子与 5-FU 之间的氢键相互作用。升高温度或溶液的 pH 值，观察到持续和控制的药物释放。化学交联是一种有效的方法，可以在初始阶段降低药物释放率。具有环境敏感特性的新型复合纳米粒子有望在智能药物输送系统领域得到应用。
